玄府理论指导下运用自拟凉血润肤方治疗寻常型银屑病的效果观察  

Effect observation of self-made blood cooling and moisturizing formula in the treatment of patients with psoriasis vulgaris

作　　者：魏梦妍 谢苗[2] 刘传丽 WEI Mengyan;XIE Miao;LIU Chuani(Dept.of Dermatology,Zhengzhou Jinshui District General Hospital,Zhengzhou 450000;School of Traditional Chinese Medicine,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]郑州市金水区总医院皮肤科,河南郑州450000 [2]河南中医药大学中医学院,河南郑州450046

出　　处：《华夏医学》2023年第6期165-169,共5页Acta Medicinae Sinica

摘　　要：目的:观察玄府理论指导下运用自拟凉血润肤方治疗寻常型银屑病患者的效果。方法:采用随机数字表法将113例寻常型银屑病患者分成两组,对照组56例接受西医卡泊三醇软膏治疗,观察组57例加用自拟凉血润肤方治疗。比较两组患者外周血Th17相关效应因子水平以及皮肤屏障功能。结果:治疗后,观察组严重程度指数(PASI)评分、皮肤经皮水分丢失值(TEWL)均低于对照组,白细胞介素-17(IL-17)、白细胞介素-23(IL-23)的水平均低于对照组,以上差异有统计学意义(P<0.05)。治疗后,观察组角质层含水量、皮脂含量均高于对照组(P<0.05)。结论:玄府理论指导下运用自拟凉血润肤方治疗寻常型银屑病患者,可改善皮肤屏障功能,减轻银屑病严重程度,效果确切。Objective:To observe the effects of self-made blood cooling and moisturizing formula on patients with psoriasis vulgaris under the guidance of Xuanfu theoryn.Methods:A total of 113 patients with psoriasis vulgaris in our hospital were divided into two groups using a random number table.56 patients in the control group were treated with Western medicine capotriol ointment,and 57 patients in the observation group were treated with self-designed blood cooling lotion.The levels of TH17 related efficient factors in peripheral blood and skin barrier function were compared between the two groups.Results:After treatment,the psoriasis area and severity index(PASI)score,interleukin-17(IL-17),IL-23 and transepidermal water loss value(TEWL)levels in the observation group were lower than those in the control group(P<0.05),and the water content and sebum content in stratum corneum were higher than those in control group(P<0.05).Conclusion:Based on the Xuanfu theory,the self-made Liangxue Runfu recipe has a significant effect in the treatment of psoriasis vulgaris patients,especially in reducing Th-related effectors,improving skin barrier function,and reducing the severity of psoriasis.

关 键 词：玄府理论 自拟凉血润肤方 寻常型银屑病 皮肤屏障功能 

分 类 号：R275.9[医药卫生—中西医结合]