冠心病患者糖脂代谢水平与心肌缺血程度的相关性  

Correlation between the level of glucose-lipid metabolism and myocardial ischemia in patients with coronary heart disease

作　　者：石凡[1] 吴春华[1] 熊杰 张文强 SHI Fan;WU Chunhua;XIONG Jie;ZHANG Wenqiang(Department of Cardiology,Jiujiang First People's Hospital,Jiujiang,Jiangxi,332000,China)

机构地区：[1]九江市第一人民医院心内科,江西九江332000

出　　处：《当代医学》2023年第28期50-53,共4页Contemporary Medicine

摘　　要：目的分析冠心病患者糖脂代谢水平与心肌缺血程度的相关性。方法选取2018年12月至2020年12月九江市第一人民医院确诊的60例冠心病患者作为研究对象,根据血流储备分数(FFR)测量结果分为心肌缺血组(FFR<0.80,n=33)和无心肌缺血组(FFR≥0.80,n=27),两组均进行糖脂代谢水平检测,比较两组糖脂代谢水平,分析糖脂代谢水平与FFR的相关性。结果心肌缺血组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)水平均高于无心肌缺血组,差异有统计学意义(P<0.05);心肌缺血组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均明显高于无心肌缺血组,而高密度脂蛋白胆固醇(HDL-C)水平明显低于无心肌缺血组,差异有统计学意义(P<0.05);FPG、2hPG、HbAlc、TC、TG、LDL-G、HDL-C水平与FFR均呈负相关(P<0.05)。结论冠心病患者的糖脂代谢水平与FFR呈现一定的负相关,可用于评估冠心病的心肌缺血程度。Objective To analyze the correlation between the level of glucose-lipid metabolism and myocardial ischemia in patients with coro-nary heart disease.Methods A total of 60 patients with coronary heart disease confirmed in Jiujiang First People's Hospital from December 2018 and December 2020 were selected as the research subjects,they were divided into the myocardial ischemia group(fractional flow reserve[FFR]<0.80,n=33)and the non-ischemia group(FFR≥0.80,n=27)according to the measurement results of FFR.The level of glucose-lipid metabolism was detected in the two groups,and the level of glucose and lipid metabolism was compared between the two groups,the correlation between the level of glucose-lipid metabolism and FFR were analyzed.Results The levels of fasting plasma glucose(FPG),2 h postprandial plasma glucose(2 h PG)and glycated hemoglobin Alc(HbAlc)in the myocardial ischemia group were higher than those in the non-myocardial ischemia group,and the differ-ences were statistically significant(P<0.05);the levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in the myocardial ischemia group were significantly higher than those in the non-myocardial ischemia group,while level of high density lipoprotein cholesterol(HDL-C)was significantly lower than that in the non-myocardial ischemia group,and the differences were statistically significant(P<0.05).The levels of FPG,2 h PG,HbAlc,TC,TG,LDL-G and HDL-C were negatively correlated with FFR(P<0.05).Conclusion There is a nega-tive correlation between glucose and lipid metabolism and FFR in patients with coronary heart disease,which can be used to evaluate the degree of myocardial ischemia in coronary heart disease.

关 键 词：冠心病 糖脂代谢 血流储备分数 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]