小剂量红霉素联合孟鲁司特钠与布地奈德吸入剂治疗儿童难治性哮喘的临床效果  

Clinical Effect of Low Dose Erythromycin Combined with Montelukast Sodium and Budesonide Inhalant in the Treatment of Refractory Asthma in Children

作　　者：顾婷[1] 顾圆 张敏 GU Ting;GU Yuan;ZHANG Min(The First People's Hospital of Taicang City,Taicang 215400,China;不详)

机构地区：[1]太仓市第一人民医院,江苏太仓215400

出　　处：《中外医学研究》2024年第3期114-118,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究小剂量红霉素联合孟鲁司特钠与布地奈德吸入剂治疗儿童难治性哮喘的临床效果。方法:选取2016年1月—2022年12月太仓市第一人民医院收治的82例难治性哮喘患儿,将患儿随机分为对照组(n=40)和观察组(n=42),其中对照组应用孟鲁司特钠口服与布地奈德吸入剂联合方案治疗,观察组在此基础上联合小剂量红霉素治疗,连续治疗30 d。比较两组临床疗效、症状缓解时间、治疗前后肺功能指标及炎症和免疫标志物。结果:与对照组比较,观察组治疗总有效率更高,差异有统计学意义(P<0.05)。与对照组比较,观察组咳嗽和喘息缓解时间更短,差异有统计学意义(P<0.05)。两组治疗前肺功能比较,差异无统计学意义(P>0.05),治疗后,两组肺功能均有改善,且观察组的用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、最大呼气流量(PEF)、用力呼气75%肺活量的瞬间流速(FEF_(75))及最大呼气中期流速(MMEF)水平更高,差异有统计学意义(P<0.05)。两组治疗前嗜酸性粒细胞、免疫球蛋白G(IgG)及免疫球蛋白E(IgE)水平比较,差异无统计学意义(P>0.05);治疗后,两组嗜酸性粒细胞、IgG及IgE水平均低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。结论:应用小剂量红霉素联合孟鲁司特钠与布地奈德吸入剂治疗儿童难治性哮喘可以显著提高临床疗效,提高患儿肺功能指标,降低炎症和免疫标志物。Objective:To study the clinical effect of low dose Erythromycin combined with Montelukast Sodium and Budesonide inhalant in the treatment of refractory asthma in children.Method:A total of 82 children with refractory asthma admitted to the First People's Hospital of Taicang City from January 2016 to December 2022 were selected,they were randomly divided into control group(n=40)and observation group(n=42).The control group was treated with Montelukast Sodium oral and Budesonide inhalant combined regimen,and the observation group was treated with low-dose Erythromycin on this basis.The patients were treated for 30 d.The clinical efficacy,symptom remission time,pulmonary function indexes and inflammatory immune markers before and after treatment were compared between the two groups.Result:Compared with the control group,the total effective rate of the observation group was higher,and the difference was statistically significant(P<0.05).Compared with the control group,the remission time of cough and wheezing in the observation group were shorter,and the differences were statistically significant(P<0.05).There were no significant differences in pulmonary function between the two groups before treatment(P>0.05).After treatment,pulmonary function was improved in both groups,the levels of forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1)),peak expiratory flow(PEF),instantaneous flow rate of 75%forced expiratory flow(FEF_(75))and maximal mid-expiratory flow curve(MMEF)in the observation group were higher,the differences were statistically significant(P<0.05).There were no significant differences in the levels of eosinophils,immunoglobulin G(IgG)and immunoglobulin E(IgE)between the two groups before treatment(P>0.05).After treatment,the levels of eosinophils,IgG and IgE in both groups were lower than those before treatment,and the observation group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion:The use of low-dose Erythromycin combined with

关 键 词：难治性哮喘 红霉素 孟鲁司特钠 布地奈德 临床疗效 

分 类 号：R725.6[医药卫生—儿科]