贝那普利联合重组人脑利钠肽治疗充血性心力衰竭的效果  

Effect of Benazepril Combined with Recombinant Human Brain Natriuretic Peptide in the Treatment of Congestive Heart Failure

作　　者：李方艳 郑苗 阮婧佳 LI Fangyan;ZHENG Miao;RUAN Jingjia(The First Hospital of Wuhan,Wuhan 430030,China;不详)

机构地区：[1]武汉市第一医院,湖北武汉430030

出　　处：《中外医学研究》2024年第3期145-149,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究贝那普利联合重组人脑利钠肽治疗充血性心力衰竭的效果。方法:选取2020年3月—2023年3月武汉市第一医院心血管内科接受治疗的106例充血性心力衰竭患者,按照随机数表法分为两组,各53例。单独组采用重组人脑利钠肽进行治疗,联合组采用贝那普利联合重组人脑利钠肽治疗。比较两组每搏输出量(SV)、心排血量(CO)、左心室射血分数(LVEF)、左室舒张末期内径(LVEDD)、去甲肾上腺素(NE)、内皮素-1(ET-1)、N末端B型利钠肽原(NT-proBNP)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、可溶性细胞间粘附分子-1(sICAM-1)、促甲状腺激素(TSH)、三碘甲状腺原氨酸(T3),统计并比较两组治疗有效率和不良反应发生率。结果:治疗后,联合组SV、LVEF、T_(3)、CO、治疗总有效率高于单独组,LVEDD、NE、ET-1、NT-proBNP、IL-6、CRP、TNF-α、sICAM-1水平低于单独组,差异有统计学意义(P<0.05);两组TSH水平比较,差异无统计学意义(P>0.05)。联合组不良反应发生率高于单独组,差异无统计学意义(P>0.05)。结论:充血性心力衰竭患者采用贝那普利联合重组人脑利钠肽治疗,可改善心功能、血清神经激素因子水平,减轻炎症反应。Objective:To explore the effect of Benazepril combined with Recombinant Human Brain Natriuretic Peptide in the treatment of congestive heart failure.Method:A total of 106 patients with congestive heart failure who received treatment in the Cardiovascular Department of the First Hospital of Wuhan from March 2020 to March 2023 were selected and divided into two groups by random number table method,with 53 cases in each group.The single group was treated with Recombinant Human Brain Natriuretic Peptide,and the combined group was treated with Benazepril combined with Recombinant Human Brain Natriuretic Peptide.The stroke volume(SV),cardiac output(CO),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),noradrenaline(NE),endothelin-1(ET-1),N-terminal pro-brain natriuretic peptide(NT-proBNP),interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),soluble intercellular cell adhesion molecule-1(sICAM-1),thyroid stimulating hormone(TSH)and triiodothyronine(T_(3))between the two groups were compared,the effective rate and the incidence of adverse reactions were compared between the two groups.Result:After treatment,the levels of SV,LVEF,T3,CO and total effective rate in combined group were higher than those in single group,while the levels of LVEDD,NE,ET-1,NT-proBNP,IL-6,CRP,TNF-αand sICAM-1 were lower than those in single group,the differences were statistically significant(P<0.05).There was no significant difference in TSH level between the two groups(P>0.05).The incidence of adverse reactions in combined group was higher than that in single group,and the difference was not statistically significant(P>0.05).Conclusion:Patients with congestive heart failure treated with Benazepril combined with Recombinant Human Brain Natriuretic Peptide can improve cardiac function,serum levels of neurohormone factors and reduce inflammation.

关 键 词：贝那普利 重组人脑利钠肽 充血性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]