柴胡疏肝散加味对焦虑性失眠患者情绪状态及相关神经递质的影响  

Effects of Chaihu Shugan Powder Modified on Emotional States and Related Neurotransmitters in Patients with Anxiety Insomnia

作　　者：张岩 ZHANG Yan(Beijing Jiangong Hospital,Beijing 100054,China)

机构地区：[1]北京市健宫医院,北京100054

出　　处：《中外医学研究》2023年第36期43-47,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨柴胡疏肝散加味对焦虑性失眠患者情绪状态及相关神经递质的影响。方法:选取2020年9月—2022年10月在北京市健宫医院就诊的120例焦虑性失眠患者,采用电脑随机法将患者分为对照组和观察组,各60例。根据脱落及剔除标准,最终观察组纳入58例,对照组纳入57例。对照组给予艾司唑仑片治疗,观察组在对照组的基础上联合柴胡疏肝散加味治疗。治疗4周后,比较两组临床疗效、睡眠质量、焦虑情况、相关神经递质水平及不良反应发生情况。结果:观察组临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组匹兹堡睡眠质量指数量表(PSQI)评分、汉密尔顿焦虑量表(HAMA)评分比较,差异无统计学意义(P>0.05);治疗后,两组PSQI评分、HAMA评分均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组5-羟色胺(5-HT)、谷氨酸(Glu)、多巴胺(DA)、γ-氨基丁酸(GABA)水平比较,差异无统计学意义(P>0.05);治疗后,两组5-HT、GABA水平高于治疗前,Glu、DA水平低于治疗前,且观察组5-HT、GABA水平高于对照组,Glu、DA水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:柴胡疏肝散加味能提高焦虑性失眠治疗效果,改善睡眠质量,缓解焦虑情绪,调节神经递质水平从而调整睡眠-觉醒周期平衡,不增加不良反应。Objective:To explore the effects of Chaihu Shugan Powder Modified on emotional state and related neurotransmitters in patients with anxiety insomnia.Method:A total of 120 patients with anxiety insomnia who were treated in Beijing Jiangong Hospital from September 2020 to October 2022 were selected and divided into control group and observation group by computer randomized method,with 60 patients in each group.According to the shedding and elimination criteria,a total of 58 cases were included in the observation group and 57 cases in the control group.The control group was treated with Estazolam Tablets,and the observation group was treated with Chaihu Shugan Powder Modified on the basis of the control group.After 4 weeks of treatment,the clinical efficacy,sleep quality,anxiety,levels of related neurotransmitters and the occurrence of adverse reactions were compared between the two groups.Result:The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in scores of Pittsburgh sleep quality index(PSQI)and Hamilton anxiety scale(HAMA)between the two groups(P>0.05).After treatment,PSQI scores and HAMA scores in both groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in 5-hydroxytryptamine(5-HT),glutamic acid(Glu),dopamine(DA)and gamma-aminobutyric acid(GABA)between the two groups(P>0.05).After treatment,the levels of 5-HT and GABA in two groups were higher than those before treatment,the levels of Glu and DA were lower than those before treatment,and the levels of 5-HT and GABA in observation group were higher than those in control group,the levels of Glu and DA were lower than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in th

关 键 词：失眠 焦虑 柴胡疏肝散加味 情绪状态 神经递质 

分 类 号：R256.23[医药卫生—中医内科学]