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作 者:王思思[1] 肖逵 李孝建[1] WANG Sisi;XIAO Kui;LI Xiaojian(Guangzhou Red Cross Hospital of Jinan University,Guangzhou 510000,China;不详)
机构地区:[1]暨南大学附属广州红十字会医院,广东广州510000
出 处:《中外医学研究》2024年第2期167-171,共5页CHINESE AND FOREIGN MEDICAL RESEARCH
基 金:广州市科技计划项目(202201020003)。
摘 要:缺血-再灌注(I/R)是急性肾损伤(AKI)的常见原因,常见于肾移植、休克、创伤、泌尿外科和心血管外科手术,对此尚无有效的治疗方法。铁死亡是一种新发现的调节性细胞死亡模式,其特征是铁依赖性脂质过氧化物的致命积累。已有大量研究表明,铁死亡参与I/R AKI的发生发展,其病理生理机制及治疗靶点逐渐成为研究的热点。本文概述了近年来关于I/R AKI中铁死亡的相关研究进展,旨在为I/R AKI的预防及治疗提供新的思路和策略。Ischemia-reperfusion(I/R)is a common cause of acute kidney injury(AKI),and is commonly seen in kidney transplantation,shock,trauma,urology and cardiovascular surgery,for which there is no effective treatment.Ferroptosis is a newly discovered mode of regulatory cell death,it is characterized by a fatal accumulation of iron-dependent lipid peroxides.A large number of studies have shown that ferroptosis is involved in the occurrence and development of I/R AKI,and its pathophysiological mechanism and therapeutic targets have gradually become a focus of research.This article reviews the recent research progress on ferroptosis in I/R AKI,aiming to provide new ideas and strategies for the prevention and treatment of I/R AKI.
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