血府逐瘀汤加减联合盐酸赛庚啶片治疗血瘀型偏头痛的临床观察  

Clinical Observation of Modified Xuefu Zhuyu Decoction Combined with Cyprohepidine Hydrochloride Tablets in the Treatment Migraine of Blood-Stasis Pattern

作　　者：师虹艳 杨少坤 荀军锋 张晨柳 李智申 SHI Hongyan;YANG Shaokun;XUN Junfeng;ZHANG Chenliu;LI Zhishen(Dept.of Encephalopathy,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)

机构地区：[1]石家庄市中医院脑病科,石家庄050000

出　　处：《中国医院用药评价与分析》2023年第12期1450-1453,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省中医药管理局科研计划项目(No.2023149)。

摘　　要：目的:探讨血府逐瘀汤加减联合盐酸赛庚啶片治疗血瘀型偏头痛患者的临床疗效。方法:选择2021年2月至2023年2月于该院就诊的血瘀型偏头痛患者92例,根据随机数字表法分为观察组与对照组,各46例。对照组患者给予盐酸赛庚啶片治疗,观察组患者在对照组的基础上给予血府逐瘀汤加减治疗。观察两组患者治疗前后的临床疗效、中医证候评分、症状改善情况(头痛发作次数、头痛持续时间、头痛视觉模拟评分和偏头痛特异性生活质量问卷评分)、血清神经递质(降钙素基因相关肽、5-羟色胺和多巴胺)水平、脑动脉血流速度(大脑前动脉、大脑中动脉、大脑后动脉和椎动脉)、复发率及安全性。结果:治疗后,观察组患者的总有效率为91.30%(42/46),显著高于对照组的73.91%(34/46),差异有统计学意义(P<0.05)。治疗后,两组患者中医证候评分、头痛视觉模拟评分均较治疗前降低,头痛发作次数较治疗前减少,头痛持续时间较治疗前缩短,脑动脉血流速度较治疗前减慢,且观察组患者上述指标较对照组明显改善,差异均有统计学意义(P<0.05)。两组患者治疗后血清降钙素基因相关肽、5-羟色胺和多巴胺水平,偏头痛特异性生活质量问卷评分均较治疗前升高,且观察组患者高于对照组,差异均有统计学意义(P<0.05)。观察组患者随访过程中的复发率为6.52%(3/46),显著低于对照组的23.91%(11/46),差异有统计学意义(P<0.05)。结论:血府逐瘀汤加减联合盐酸赛庚啶片治疗血瘀型偏头痛的临床疗效显著。OBJECTIVE:To explore the clinical efficacy of modified Xuefu Zhuyu decoction combined with Cyprohepidine hydrochloride tablets in the treatment migraine of blood-stasis pattern.METHODS:Totally 92 patients with migraine of blood-stasis pattern admitted into the hospital from Feb.2021 to Feb.2023 were extrected to be divided into the observation group and the control group via the random number table method,with 46 cases in each group.The control group was treated with Cyprohepidine hydrochloride tablets,while the observation group received Xuefu Zhuyu decoction on the basis of the control group.The clinical efficacy,traditional Chinese medicine syndrome score and symptom improvement(headache attack frequency,headache duration,headache visual simulation score and migraine specific quality of life questionnaire score),serum neurotransmitters(calcitonin gene-related peptide,5-hydroxytryptamine and dopamine),cerebral artery flow velocity(anterior cerebral artery,middle cerebral artery,posterior cerebral artery and vertebral artery),recurrence rate and safety of two groups were observed before and after treatment.RESULTS:After treatment,the total effective rate of observation group was 91.30%(42/46),significantly higher than that of control group 73.91%(34/46),with statistically significant difference(P<0.05).After treatment,the traditional Chinese medicine syndrome score,headache visual simulation score,headache attack frequency,headache duration and cerebral artery blood flow velocity of two groups were lower than those before treatment,the above indicators in observation group were improved more significantly compared with control group,the differences were statistically significant(P<0.05).The levels of serum calcitonin gene-related peptide,5-hydroxytryptamine,dopamine and migraine specific quality of life questionnaire in both groups after treatment were higher than those before treatment,and the observation group was higher than the control group,with statistically significant differences(P<0.05).The recurrence r

关 键 词：血府逐瘀汤 盐酸赛庚啶片 血瘀型 偏头痛 神经递质 脑动脉血流 

分 类 号：R932[医药卫生—生药学] R986[医药卫生—药学]