3032例患者的乌司他丁应用合理性分析  

Rationality Analysis of Ulinastatin in 3032 Patients

作　　者：张娟[1] 王颖琳[1] 姜善玲[1] 刘雪艳[1] 刘雨[2] 赵泉[1] 霍雪臣[1] ZHANG Juan;WANG Yinglin;JIANG Shanling;LIU Xueyan;LIU Yu;ZHAO Quan;HUO Xuechen(Dept.of Pharmacy,Yantai Yuhuangding Hospital,Shandong Yantai 264000,China;Dept.of Pharmacy,Affiliated Hospital of Qingdao University,Shandong Qingdao 266000,China)

机构地区：[1]烟台毓璜顶医院药学部,山东烟台264000 [2]青岛大学附属医院药学部,山东青岛266000

出　　处：《中国医院用药评价与分析》2023年第12期1512-1515,1520,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：北京医卫健康公益基金会项目(No.B17133-Q6)。

摘　　要：目的:了解乌司他丁的临床应用特征,为规范其临床应用和药品说明书更新提供参考和依据。方法:回顾性收集烟台毓璜顶医院的医院信息系统中2021年1月至2022年6月3032例使用乌司他丁的住院患者信息,对其基本资料及临床用药信息等进行统计分析。结果:3032例使用乌司他丁的患者中,男性患者居多,占59.96%(1818例);平均年龄为(60.92±14.28)岁。乌司他丁使用病例数排序居前3位的科室为心外科、消化内科和肝胆外科;符合药品说明书适应证的共742例(占24.47%),其余为超适应证用药,有较高级别循证证据的超说明书用药共1977例(占65.20%)。乌司他丁的单次剂量、溶剂及用药频次合理,未见相关不良反应发生。全院乌司他丁平均药物利用指数为0.59(<1),总体用量合理。结论:乌司他丁超适应证用药现象普遍,应采取相关措施规范其临床应用;对于循证证据充分、临床普遍使用的用法,建议药品生产企业及时更新修订药品说明书。OBJECTIVE:To investigate the clinical application characteristics of ulinastatin,so as to provide reference and basis for standardizing its clinical application and updating drug instructions.METHODS:Clinical data of 3032 inpatients with ulinastatin from Jan.2021 to Jun.2022 in the hospital information system of Yantai Yuhuangding Hospital was retrospectively collected,the basic data and clinical medication information were statistically analyzed.RESULTS:The majority of 3032 patients with ulinastatin were male,accounting for 59.96%(1818 cases),with an average age of(60.92±14.28)years.The top three departments ranked by case number of ulinastatin were cardiac surgery,gastroenterology and hepatobiliary surgery.A total of 742 cases(24.47%)met the indications of drug instructions,the rest were off-label drug use,and there were 1977 cases(65.20%)of off-label drug use with higher level evidence-based evidence.The single dose,solvent and frequency of ulinastatin were rational,and no related adverse drug reactions occurred.The average drug utilization index of ulinastatin in the hospital was 0.59(<1),the overall dosage was rational.CONCLUSIONS:The off-label use of ulinastatin is common,and relevant measures should be taken to standardize the clinical application.For application with sufficient evidence-based evidence and common clinical use,it is recommended that drug manufacturers update and revise the drug inserts in a timely manner.

关 键 词：乌司他丁 合理用药 超说明书用药 

分 类 号：R969.3[医药卫生—药理学] R979.9[医药卫生—药学]