双歧杆菌四联活菌片联合吡拉西坦对重症脑出血患者胃肠功能及神经功能的影响  

Effects of Bifidobacterium Quadruple Viable Tablet Combined with Piracetam on Gastrointestinal Function and Neurological Function in Patients with Severe Cerebral Hemorrhage

作　　者：黄涛[1] 吕凤华 张伟丹 HUANG Tao;LYU Fenghua;ZHANG Weidan(Dept.of Emergency and Critical Care,Dezhou Hospital,Qilu Hospital,Shandong University,Shandong Dezhou 253000,China;Dept.of Neurology,Dezhou Hospital,Qilu Hospital,Shandong University,Shandong Dezhou 253000,China)

机构地区：[1]山东大学齐鲁医院德州医院急诊重症医学科,山东德州253000 [2]山东大学齐鲁医院德州医院神经内科,山东德州253000

出　　处：《中国医院用药评价与分析》2024年第1期18-21,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：山东省科技计划项目(No.20202217)。

摘　　要：目的:探讨双歧杆菌四联活菌片联合吡拉西坦对重症脑出血患者胃肠功能及神经功能的影响。方法:选取2021—2022年该院治疗的重症脑出血患者50例,采用随机数字表法分为对照组24例、研究组26例。对照组患者给予吡拉西坦进行治疗,研究组患者给予双歧杆菌四联活菌片联合吡拉西坦进行治疗。检测两组患者的脑血管平均流速、脑血管平均流量、血管外周阻力和动态阻力水平;采用格拉斯哥昏迷评分(GCS)、日常生活活动评分(ADL)评估患者昏迷程度及日常生活能力;检测乳杆菌、双歧杆菌、D-乳酸(D-LC)、二胺氧化酶(DAO)、神经肽Y(NPY)和铁蛋白水平;采用美国国立卫生院卒中神经功能缺损评分量表(NIHSS)评估患者神经功能缺损情况;对比两组患者的治疗效果。结果:治疗后,研究组患者脑血管平均流速、脑血管平均流量水平、GCS和ADL评分高于对照组;血管外周阻力、动态阻力,D-LC、DAO、NPY、铁蛋白水平和NIHSS评分低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组患者的总有效率为92.31%(24/26),高于对照组的66.67%(16/24),差异有统计学意义(P<0.05)。结论:双歧杆菌四联活菌片与吡拉西坦联合治疗,能显著恢复重症脑出血患者的胃肠功能及神经功能,改善脑血管功能,恢复肠道菌群平衡,提升患者意识状态,提高日常生活能力,临床治疗效果显著。OBJECTIVE:To explore the effects of Bifidobacterium quadruple viable tablet combined with piracetam on gastrointestinal function and neurological function in patients with severe cerebral hemorrhage.METHODS:Fifty patients with severe cerebral hemorrhage admitted into the hospital from 2021 to 2022 were extracted to be divided into the control group(n=24)and study group(n=26)via the random number table method.The control group was treated with piracetam,while the study group received Bifidobacterium quadruple viable tablet combined with piracetam.The average cerebrovascular flow rate,average cerebrovascular flow,vascular peripheral resistance and dynamic resistance level were detected.The Glasgow coma score(GCS)and activities of daily living(ADL)scores were used to assess the degree of coma and ability to perform activities of daily living.Lactobacillus,Bifidobacterium,D-lactic acid(D-LC),diamine oxidase(DAO),neuropeptide Y(NPY)and ferritin level were detected.The national institutes of health neurologic deficit scale for stroke(NIHSS)was used to assess the neurologic deficits.Therapeutic effect of two groups was compared.RESULTS:After treatment,the mean cerebrovascular flow rate,mean cerebrovascular flow level,GCS,ADL scores of the study group were higher than those of the control group;the peripheral vascular resistance,dynamic resistance,D-LC,DAO,NPY,ferritin,NIHSS scores of the study group were lower than those of the control group,with statistically significant differences(P<0.05).After treatment,the total effective rate of the study group was 92.31%(24/26),higher than 66.67%(16/24)of the control group,the difference was statistically significant(P<0.05).CONCLUSIONS:Bifidobacterium quadruple viable tablet combined with piracetam can significantly restore the gastrointestinal function and neurological function of patients with severe cerebral hemorrhage,improve the cerebrovascular function,restore the balance of intestinal flora,enhance the conscious state,improve the ability of daily life,and the clinical the

关 键 词：重症脑出血 双歧杆菌四联活菌片 吡拉西坦 胃肠功能 神经功能 

分 类 号：R975[医药卫生—药品]