脑心通胶囊联合盐酸多奈哌齐治疗多发性梗死性痴呆的疗效和安全性  

Efficacy and Safety of Naoxintong Capsules Combined with Donepezil Hydrochloride in the Treatment of Multiple Infarct Dementia

作　　者：沈连华 张冬梅[2] 崔杨慧 SHEN Lianhua;ZHANG Dongmei;CUI Yanghui(Dept.of Emergency,Hai’an People’s Hospital,Jiangsu Hai’an 226600,China;Dept.of Neurology,Nantong First People’s Hospital,Jiangsu Nantong 226001,China)

机构地区：[1]海安市人民医院急诊科,江苏海安226600 [2]南通市第一人民医院神经内科,江苏南通226001

出　　处：《中国医院用药评价与分析》2024年第1期38-41,46,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：江苏省卫生健康委医学科研课题(No.H2018035)。

摘　　要：目的:探讨脑心通胶囊联合盐酸多奈哌齐治疗多发性梗死性痴呆(MID)的临床效果和安全性。方法:选取2020年7月至2022年6月海安市人民医院急诊科收治的MID患者85例,采用抽签法分为观察组(n=44)和对照组(n=41)。两组患者均给予生活干预和常规治疗措施,对照组患者采用盐酸多奈哌齐口服,观察组患者采用脑心通胶囊联合盐酸多奈哌齐口服。观察两组患者炎症和氧化应激、血液流变学、脑血流动力学和神经功能指标的变化,以及药品不良反应发生情况。结果:治疗8周后,观察组患者的可溶性细胞间黏附分子、白细胞介素18、丙二醛、全血高切黏度、全血低切黏度和纤维蛋白原水平明显低于对照组,超氧化物歧化酶水平、大脑中动脉峰值流速和平均血流速度明显高于对照组,差异均有统计学意义(P<0.05)。观察组患者的蒙特利尔认知评测量表和长谷川简易智能评定量表评分明显高于对照组,差异均有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为9.09%(4/44)、7.32%(3/41),差异无统计学意义(P>0.05)。结论:在盐酸多奈哌齐的基础上加用脑心通胶囊,可减轻MID患者的炎症反应、氧化反应,改善血液流变学异常,提高脑血液灌注量,促进神经功能恢复,安全性高。OBJECTIVE:To probe into the clinical efficacy and safety of Naoxintong capsules combined with donepezil hydrochloride in the treatment of multiple infarct dementia(MID).METHODS:Totally 85 patients with MID admitted into the emergency department of Hai'an People's Hospital from Jul.2020 to Jun.2022 were extracted to be divided into the observation group(n=44) and control group(n=41) by lottery method.Both groups were given life intervention and conventional treatment measures.The control group was treated with donepezil hydrochloride orally,while the observation group received Naoxintong capsules combined with donepezil hydrochloride orally.Changes of inflammation and oxidative stress,hemorheology,cerebral hemodynamics,neural function indicators,and adverse drug reactions were observed.RESULTS:After 8 weeks of treatment,the levels of soluble intercellular adhesion molecules,interleukin18,malondialdehyde,high cut whole blood viscosity,low cut whole blood viscosity and fibringen in observation group were significantly lower than those in control group,while the levels of superoxide dismutase,peak flow velocity of middle cerebral artery and average blood flow velocity were significantly higher than those in control group,with statistically significant differences(P<0.05).The Montreal cognitive assessment scale and Hasegawa simple intelligence rating scale in the observation group were significantly higher than those in the control group,with statistically significant differences(P<0.05).The incidence of adverse drug reactions in observation group and control group was respectively 9.09%(4/44) and 7.32%(3/41),with no statistical significance(P>0.05).CONCLUSIONS:Naoxintong capsules combined with donepezil hydrochloride can reduce the inflammation and oxidation reaction in MID patients,improve the abnormal hemorheology,increase the cerebral blood perfusion volume,and promote the recovery of nerve function with higher safety.

关 键 词：多发性梗死性痴呆 脑心通胶囊 炎症 脑灌注 认知功能 安全性 

分 类 号：R932[医药卫生—生药学] R971[医药卫生—药学]