临床药师参与坏死性筋膜炎抗感染用药会诊的回顾性分析  

Retrospective Analysis on Participation of Clinical Pharmacists in Consultation of Anti-Infective Medication for Necrotizing Fasciitis

作　　者：刘燕飞 李金卓 陈思韵 黄仁彬[1] 陆华[3] LIU Yanfei;LI Jinzhuo;CHEN Siyun;HUANG Renbin;LU Hua(School of Pharmacy,Guangxi Medical University,Nanning 530021,China;Dept.of Pharmacy,the People,s Hospital of Hezhou,Guangxi Hezhou 542899,China;Dept.of Pharmacy,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学药学院,南宁530021 [2]贺州市人民医院药学部,广西贺州542899 [3]广西医科大学第一附属医院药学部,南宁530021

出　　处：《中国医院用药评价与分析》2024年第1期113-115,118,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：广西壮族自治区贺州市科学研究与技术开发计划项目(No.贺科技:20061)。

摘　　要：目的:通过对临床真实病例的回顾性分组比较,探讨临床药师参与坏死性筋膜炎患者抗感染用药会诊的效果。方法:收集2017年6月至2022年6月贺州市人民医院101例坏死性筋膜炎住院患者的病例资料,通过有无临床药师会诊分为会诊组(48例)和非会诊组(53例),比较两组患者的性别、年龄、基础疾病、科室分布、感染部位、严重程度、手术情况、抗菌药物使用情况、相关住院费用及预后等指标。结果:与非会诊组比较,会诊组患者感染程度严重、合并基础疾病多、手术干预例数多、混合感染例数多、住院时间长,差异均有统计学意义(P<0.05);两组患者在抗菌药物联合应用、特殊使用级抗菌药物和限制使用级抗菌药物的使用方面比较,差异无统计学意义(P>0.05);会诊组患者平均抗菌药物使用时间长于非会诊组,住院费用高于非会诊组,但差异无统计学意义(P>0.05);会诊组患者抗菌药物使用强度低于非会诊组。结论:临床药师参与坏死性筋膜炎患者抗感染用药会诊,有助于提高治疗效果,体现了临床药师的价值。OBJECTIVE:Through comparison of retrospective subgroups of real clinical cases,to analyze the participation of clinical pharmacists in consultation of anti-infective medication for necrotizing fasciitis,so as to reflect the role of clinical pharmacists.METHODS:The case data of 101 inpatients with necrotizing fasciitis in the People~,s Hospital of Hezhou from Jun.2017 to Jun.2022 were collected and divided into consultation group(48 cases)and non-consultation group(53 cases)according to clinical pharmacists'consultation,the indicators of genders,ages,underlying diseases,distribution of departments,sites of infection,severity degrees,surgery situation,application of antibiotics,related hospitalization costs and prognoses were compared.RESULTS:Compared with the non-consultation group,the consultation group had serious infection degree,more underlying diseases,more cases of surgical intervention,more cases of mixed infection and longer hospital stay,and the differences were statistically significant(P<0.05).There was no difference between the two groups in the combined use of antibiotics,the use of special use grade antibiotics and restricted use grade antibiotics(P>0.05).The average duration of antibiotic use in the consultation group was longer than that in the non-consultation group,and the hospitalization cost was higher than that in the non-consultation group,but no statistical difference(P>0.05);However,the intensity of antibiotic use in the consultation group was lower than that in the non-consultation group.CONCLUSIONS:Participation of clinical pharmacists in the consultation of antiinfective drugs in necrotizing fasciitis patients is helpful to improve the therapeutic effect,which reflects the value of clinical pharmacists.

关 键 词：坏死性筋膜炎 抗感染治疗 临床药师 干预 

分 类 号：R978[医药卫生—药品] R969.3[医药卫生—药学]