观察肺结核患者采用水飞蓟宾胶囊预防抗结核药物肝损害的临床效果  

Observation on the clinical effect of silybin capsule on preventing liver damage caused by anti-tuberculosis drugs in patients with pulmonary tuberculosis

作　　者：高阳[1] GAO Yang(Department of Internal Medicine,Heze Infectious Diseases Hospital,Heze 274000,China)

机构地区：[1]山东省菏泽市传染病医院内科,274000

出　　处：《中国实用医药》2024年第2期106-109,共4页China Practical Medicine

摘　　要：目的 探讨对肺结核患者采用水飞蓟宾胶囊预防抗结核药物肝损害的临床效果。方法 100例肺结核患者作为研究对象,根据入院治疗时间顺序分为实验组和对照组,各50例。对照组通过常规的抗结核方式治疗,实验组以对照组为基准增加水飞蓟宾胶囊治疗。比较两组患者的肝功能指标[谷氨酰转肽酶(GGT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBil)],不良反应发生情况,治疗效果,治疗满意度。结果 治疗后,实验组患者的ALT、AST、GGT、TBil水平显著低于治疗前,对照组患者的ALT、AST、GGT、TBil水平均高于治疗前,且实验组患者的ALT(34.65±6.23)U/L、AST(37.25±8.26)U/L、GGT(7.29±1.69)U/L、TBil(15.27±4.79)μmol/L均低于对照组的(44.76±7.15)U/L、(46.39±9.50)U/L、(12.47±3.01)U/L、(22.31±6.05)μmol/L,经统计学软件分析得出(P<0.05)。实验组不良反应发生率(14%)与对照组(18%)比较差异不大,经统计学软件分析得出(P>0.05)。治疗后,实验组总有效率(86%)高于对照组(68%),经统计学软件分析得出(P<0.05)。实验组治疗满意度(94%)高于对照组(76%),经统计学软件分析得出(P<0.05)。结论 水飞蓟宾胶囊对肺结核患者抗结核药物肝损害具有积极的预防作用,能减少不良反应的发生,可增强患者的治疗效果并提高患者的满意度,值得在临床上推广。Objective To investigate the clinical effect of silybin capsule on preventing liver damage caused by anti tuberculosis drugs in patients with pulmonary tuberculosis.Methods 100 patients with pulmonary tuberculosis were taken as the research subjects,and they were randomly divided into an experimental group and a control group by admission time,with 50 patients in each group.The control group was treated with conventional anti tuberculosis methods,and the experimental group was also treated with silybin capsules based on the control group.The liver function index[gamma glutamyl transpeptidase (GGT),alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBil)],adverse reaction rate,treatment effect and treatment satisfaction of the two groups were compared.Results After treatment,the levels of ALT,AST,GGT and TBil in the experimental group were significantly lower than those before treatment,while the levels of ALT,AST,GGT and TBil in the control group were higher than those before treatment;and ALT of (34.65±6.23) U/L,AST of(37.25±8.26) U/L,GGT of (7.29±1.69) U/L,TBil of (15.27±4.79)μmol/L in the experimental group were lower than those of (44.76±7.15) U/L,(46.39±9.50) U/L,(12.47±3.01) U/L,(22.31±6.05)μmol/L in the control group.The difference was statistically significant (P<0.05).There was no statistically significant difference in the incidence of adverse reactions between patients in the experimental group (14%) and patients in the control group(18%)(P>0.05).After treatment,the total effective rate of the experimental group (86%) was higher than that of the control group (68%),and the difference was statistically significant (P<0.05).The treatment satisfaction of patients in the experimental group (94%) was significantly higher than the control group (76%)(P<0.05).Conclusion Silybin capsule has an active therapeutic effect on anti tuberculosis drug induced liver damage in patients with pulmonary tuberculosis.It can effectively reduce the occurrence of adverse reactions and i

关 键 词：肺结核 水飞蓟宾胶囊 抗结核药物 肝损害 

分 类 号：R521[医药卫生—内科学]