腹腔镜手术联合亮丙瑞林、戊酸雌二醇治疗子宫内膜异位症的临床疗效分析  

Analysis of clinical efficacy of laparoscopic surgery combined with leuprolide and estradiol valerate in the treatment of endometriosis

作　　者：乔保华 徐淑云 QIAO Bao-hua;XU Shu-yun(Department of Gynecology,Heze Municipal Hospital,Heze 274000,China)

机构地区：[1]菏泽市立医院妇科,274000

出　　处：《中国实用医药》2024年第2期110-113,共4页China Practical Medicine

摘　　要：目的 探究腹腔镜手术联合亮丙瑞林、戊酸雌二醇治疗子宫内膜异位症(EMT)的临床疗效。方法 114例EMT患者,以随机数字表法分为对照组和观察组,每组57例。对照组给予腹腔镜手术治疗,观察组在对照组基础上加用亮丙瑞林+戊酸雌二醇治疗。比较两组临床疗效、视觉模拟评分法(VAS)评分、不良反应发生情况、复发情况及性激素[促黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E_(2))]、血管内皮生长因子(VEGF)、糖类抗原125(CA125)水平。结果 观察组总有效率(93.0%)高于对照组(80.7%),数据比较有差异(χ^(2)=4.653,P<0.05)。治疗后,观察组VAS评分为(2.94±0.73)分,低于对照组的(3.41±0.82)分,数据比较有差异(t=2.437,P<0.05)。治疗后,观察组LH、FSH、E_(2)水平较治疗前及对照组明显下降,数据比较有差异(P<0.05),而对照组LH、FSH、E_(2)数据相较治疗前无差异(P>0.05)。治疗后,两组VEGF、CA125水平均较治疗前降低,且观察组VEGF(173.09±10.67)ng/L、CA125(32.68±8.47)U/ml较对照组的(216.58±14.82)ng/L、(43.82±10.94)U/ml下降明显,数据比较有差异(P<0.05)。两组不良反应数据比较无差异(χ^(2)=0.538,P>0.05)。观察组可见3例复发,占比5.3%;对照组可见8例复发,占比14.0%;两组间复发数据比较无差异(χ^(2)=2.515,P>0.05)。结论 EMT治疗时选择腹腔镜手术+亮丙瑞林+戊酸雌二醇,与单一腹腔镜手术相比疗效更为显著,临床可选用。Objective To explore the clinical efficacy of laparoscopic surgery combined with leuprorelin and estradiol valerate in the treatment of endometriosis (EMT).Methods 114 patients with EMT were divided into a control group and an observation group according to the digital random table method,with 57 cases in each group.The control group was given laparoscopic surgery,and the observation group was given leuprorelin and estradiol valerate on the basis of the control group.Both groups were compared in terms of clinical efficacy,Kupperman score,visual analogue scale (VAS) score,adverse reactions,recurrence,sex hormone[luteinizing hormone (LH),follicle stimulating hormone (FSH),estradiol (E_(2))],vascular endothelial growth factor (VEGF)and carbohydrate antigen 125 (CA125).Results The total effective rate of the observation group (93.0%) was higher than the control group (80.7%),and the difference was significant (χ^(2)=4.653,P<0.05).After treatment,the VAS score in the observation group was (2.94±0.73) points,which was lower than that of (3.41±0.82) points in the control group,and the difference was significant (t=2.437,P<0.05).After treatment,the levels of LH,FSH and E_(2) in the observation group were significantly decreased compared with those before treatment and control group,and the difference was significant (P<0.05),while there was no difference in LH and FSH,E_(2) in the control group compared with those before treatment (P>0.05).After treatment,VEGF and CA125 levels in both groups were lower than those before treatment;VEGF of (173.09±10.67) ng/L and CA125 of (32.68±8.47) U/ml in the observation group were significantly decreased compared with those of (216.58±14.82) ng/L and (43.82±10.94) U/ml in the control group,and the difference was significant (P<0.05).There was no difference in adverse reaction between the two groups (χ^(2)=0.538,P>0.05).In the observation group,3 cases recurred,accounting for5.3%;in the control group,8 cases recurred,accounting for 14.0%.There was no difference in the recurrenc

关 键 词：戊酸雌二醇 腹腔镜手术 亮丙瑞林 子宫内膜异位症 性激素 

分 类 号：R711.71[医药卫生—妇产科学]