血必净注射液治疗脓毒症合并急性肺损伤患者的临床观察  

Clinical Observation of Xuebijing Injection in the Treatment of Sepsis Complicated with Acute Lung Injury

作　　者：马红双[1] 郭瑞[1] 李勇锋[1] MA Hongshuang;GUO Rui;LI Yongfeng(Zhengzhou Orthopaedic Hospital,Henan Zhengzhou 450000)

机构地区：[1]郑州市骨科医院,河南郑州450000

出　　处：《深圳中西医结合杂志》2023年第21期31-34,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:分析脓毒症合并急性肺损伤患者应用血必净注射液对其生命体征、血气指标及炎症因子水平的影响。方法:选取2020年4月至2023年4月郑州市骨科医院收治的127例脓毒症合并急性肺损伤患者,采用随机数表法分为对照组(63例)和观察组(64例)。对照组给予常规治疗,观察组在对照组基础上联合血必净注射液治疗。治疗1周后,比较两组患者生命体征、血气指标、炎症因子水平、不良反应发生情况。结果:治疗1周后,观察组患者心率、体温低于对照组,收缩压、舒张压高于对照组,差异具有统计学意义(P <0.05)。治疗1周后,观察组患者动脉血氧分压(PaO_(2))、动脉血氧饱和度(Sp O_(2))高于对照组,动脉血二氧化碳分压(PaCO_(2))低于对照组,差异具有统计学意义(P <0.05)。治疗1周后,观察组患者白细胞介素–6(IL–6)、肿瘤坏死因子–α(TNF–α)、C反应蛋白(CRP)水平低于对照组,差异具有统计学意义(P <0.05)。两组患者不良反应发生率比较,差异无统计学意义(P> 0.05)。结论:血必净注射液能够有效改善节脓毒症合并急性肺损伤患者血气指标,稳定生命体征,降低炎症因子水平,且安全性高。Objective To analyze the effects of Xuebijing injection on vital signs,blood gas indexes and levels of inflammatory factors in patients with sepsis complicated with acute lung injury.Methods A total of 127 patients with sepsis complicated with acute lung injury admitted to Zhengzhou Orthopaedic Hospital from April 2020 to April 2023 were selected and divided into a control group(63 cases) and an observation group(64 cases) by random number table method.The control group was given routine treatment,and the observation group was combined with Xuebijing injection on the basis of the control group.After 1 week of treatment,the vital signs,blood gas indexes,levels of inflammatory factors and occurrence of adverse reactions were compared between the two groups.Results After 1 week of treatment,the heart rate and body temperature of the observation group were lower than those of the control group,and the systolic blood pressure and diastolic blood pressure were higher than those of the control group,the differences were statistically significant(P < 0.05).After 1 week of treatment,the arterial partial pressure of oxygen(PaO_(2)) and arterial oxygen saturation(SpO_(2)) in the observation group were higher than those in the control group,and the arterial partial pressure of carbon dioxide(PaCO_(2)) was lower than that in the control group,with statistical significances(P < 0.05).After 1 week of treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α) and C-reactive protein(CRP) in the observation group were lower than those in the control group,and the differences were statistically significant(P < 0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P > 0.05).Conclusion Xuebijing injection can effectively improve blood gas indexes,stabilize vital signs,and reduce the level of inflammatory factors in patients with joint sepsis complicated with acute lung injury,with high safety.

关 键 词：脓毒症 急性肺损伤 血必净注射液 

分 类 号：R563[医药卫生—呼吸系统] R631[医药卫生—内科学]