当归四逆汤物质基础研究进展  

Research Progress on Material Basis of Danggui Sini Decoction(当归四逆汤)

作　　者：王明慧 田崇娅 丁语晨 徐园园 王加锋 魏永利[4] 辛义周[4] 马飞[4] WANG Minghui;TIAN Chongya;DING Yuchen;XU Yuanyuan;WANG Jiafeng;WEI Yongi;XIN Yizhou;MA Fei(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;College of Pharmacy,Jining Medical University,Rizhao 276826,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]济宁医学院药学院,山东日照276826 [3]山东中医药大学中医学院,山东济南250355 [4]山东中医药大学附属医院,山东济南250011

出　　处：《山东中医药大学学报》2024年第1期121-127,共7页Journal of Shandong University of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(编号:2019-0074);国家中医药管理局公益性行业专项(编号:2016-2-11);山东省中医药科技项目(编号:M-2023166)。

摘　　要：当归四逆汤是治疗血虚寒厥证的代表方剂,具有温经散寒、养血通脉等功效。现代研究发现,其具有抗凝及抗血栓形成、改善末梢及全身血液循环、抗炎镇痛、解痉、提高神经传导速度等药理活性。在对当归四逆汤化学成分、药理作用综述的基础上,基于传统植物化学分离分析、血清药物化学、代谢组学、谱效关系、网络药理学和多靶点高通量筛选等技术方法,对当归四逆汤的药效物质基础予以总结和分析,为当归四逆汤的深入开发及相关制剂的质量控制等后续研究提供参考。参考文献49篇。Danggui Sini Decoction(当归四逆汤)is a representative formula for the treatment of blood deficiency and cold reversal syndrome,which has the effect of warming meridians and expelling cold,nourishing blood and activating pulse.Modern study finds that it can play the role of anticoagulation and anti-thrombosis,improving peripheral and systemic blood circulation,anti-inflammatory and analgesic,spasmolysis,increasing nerve conduction velocity and so on.On the basis of summarizing the chemical components and pharmacological effects of Danggui Sini Decoction,the pharmacodynamic material basis of Danggui Sini Decoction was summarized and analyzed based on traditional phytochemical isolation analysis,serum pharmacochemistry,metabolomics,spec-tral effect relationship,network pharmacology and multi-target high throughput screening.It provides reference for further development of Danggui Sini Decoction and quality control of related preparations.Total 49 references are cited.

关 键 词：当归四逆汤 物质基础 化学成分 药理作用 药效 质量控制 经典名方 

分 类 号：R289.5[医药卫生—方剂学]