骨化三醇联合碳酸钙胶囊治疗糖尿病性骨质疏松患者的疗效及安全性  

Efficacy and safety analysis of calcitriol combined with calcium carbonate capsule in the treatment of diabetic osteoporosis

作　　者：杨艳君 何启胜 刘君[1] YANG Yanjun;HE Qisheng;LIU Jun(Department of Endocrinology,Chizhou People's Hospital,Chizhou 247000,China)

机构地区：[1]池州市人民医院内分泌科,安徽池州247000

出　　处：《安徽医学》2024年第1期44-47,共4页Anhui Medical Journal

基　　金：池州市2022年度社会发展领域科技攻关项目(编号:CZ22KJSFy015)。

摘　　要：目的分析骨化三醇联合碳酸钙胶囊对糖尿病性骨质疏松(DOP)患者疗效及安全性的影响。方法选取2021年1月至2022年5月池州市人民医院内分泌科收治的120例DOP患者为研究对象,依据随机数字表法分为对照组(n=60)和观察组(n=60),对照组给予碳酸钙胶囊治疗,观察组给予骨化三醇联合碳酸钙胶囊治疗。两组均治疗半年,比较两组临床疗效,治疗前后的骨密度、电解质代谢水平[血清钙(Ca)、磷(P)]及治疗期间用药副反应。结果观察组总有效率高于对照组(95.00%比83.33%),差异有统计学意义(P<0.05);两组副反应总发生率(3.33%比3.33%)差异无统计学意义(P=1.000)。与对照组相比,观察组治疗前后股骨粗隆、Wards三角区、股骨颈及腰椎L1~4部位骨密度差值和血Ca、P差值均较大(P<0.05)。结论骨化三醇联合碳酸钙胶囊可改善DOP患者疗效,增加骨密度,纠正电解质代谢水平,安全可靠。Objective To analyze the effects of calcitriol combined with calcium carbonate capsules on the efficacy,bone mineral density,electrolyte metabolism and safety of patients with diabetic osteoporosis(DOP).Methods A total of 120 DOP patients admitted to the Endocrinology Department of Chizhou People's Hospital between January 2021 and May 2022 were selected as the study objects,who were divided into control group(n=60)and observation group(n=60)according to random number table method.The control group was given calcium carbonate capsule treatment,and the observation group was given calcitriol combined with calcium carbonate capsule treatment.The efficacy of the two groups after treatment was compared.The bone mineral density and electrolyte metabolism were compared between the two groups before and after treatment.The drug safety during treatment was compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(95.00%vs 83.33%)(P<0.05),and the total incidence of side effects was not statistically significant(3.33%vs 3.33%)(P=1.000).Compared with the control group,the differences of bone mineral density(BMD),blood Ca and P in the femoral trochanter,Wards triangle,neck of femur and lumbar vertebra L1~4 before and after treatment in the observation group were larger(P<0.05).Conclusions Calcitriol combined with calcium carbonate capsule can improve the curative effect of DOP patients,increase bone density and correct electrolyte metabolism level,safety and reliability.

关 键 词：糖尿病性骨质疏松 骨化三醇 碳酸钙胶囊 骨密度 电解质代谢 

分 类 号：R587.2[医药卫生—内分泌] R580[医药卫生—内科学]