腹膜透析患者健康相关生活质量及其影响因素分析  

Analysis of health-related quality of life and its influencing factors in peritoneal dialysis patients

作　　者：杨相杰 周润哲 孟雨晴 张定欣 张瑾[3] 王盈 Yang Xiangjie;Zhou Runzhe;Meng Yuqing;Zhang Dingxin;Zhang Jin;Wang Ying(Dept of Epidemiology and Health Statistics,School of Public Health,Anhui Medical University,Hefei 230032;Dept of Cardiac Imaging Center,Hefei 230022;Dept of Nephrology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022)

机构地区：[1]安徽医科大学公共卫生学院流行病与卫生统计学系,合肥230032 [2]安徽医科大学第一附属医院心脏影像中心,合肥230022 [3]安徽医科大学第一附属医院肾脏内科,合肥230022

出　　处：《安徽医科大学学报》2024年第1期161-167,共7页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:82200833)。

摘　　要：目的利用欧洲五维健康评定量表(EQ-5D-5L)调查腹膜透析(PD)患者健康相关生活质量(HRQOL)并分析其影响因素,为改善患者生活质量提供建议。方法纳入医院肾脏内科住院治疗并规律随访的PD患者,收集患者一般人口学资料、实验室检查指标。采用6分钟步行实验(6-MWT)评估患者运动耐力,抑郁筛查评价量表(PHQ-9)评价患者抑郁状态,EQ-5D-5L量表进行HRQOL评分,多因素线性回归分析EQ-5D-5L健康效用值的影响因素。结果研究纳入90例PD患者,年龄18~70(49.44±11.41)岁,EQ-5D-5L的健康效用值最高为1.00分,最低为-0.01分,平均(0.92±0.15)分。多因素线性回归分析显示胆红素升高(β=-0.009,P=0.018)、C-反应蛋白升高(β=-0.005,P<0.001)、PHQ-9评分升高(β=-0.008,P=0.014)与PD患者EQ-5D-5L健康效用值呈负向关联,6分钟步行距离升高(β=0.005,P=0.018)与PD患者EQ-5D-5L健康效用值呈正向关联。结论胆红素和CRP水平、抑郁状态、运动耐量是影响PD患者HRQOL的主要影响因素。Objective To employ the EQ-5D-5L questionnaire to evaluate HRQOL in patients on peritoneal dialysis(PD)and investigate the related risk factors to provide suggestions for improving quality of life.Methods PD patients who were followed up regularly in the department of nephrology were recruited in this study.Demographic characteristics and laboratory data were collected.Exercise capacity was assessed by the 6-MWT.PHQ-9 was conducted to screen depression status.The EQ-5D-5L questionnaire was used to evaluate HRQOL.Multivariate linear regression analysis was used to examine the potential influencing factors of EQ-5D-5L health utility value.Results Among recruited 90 PD patients,the mean age was(49.44±11.41)years and range from 18 to 70.The highest health utility value of EQ-5D-5L was 1 point,while the lowest was-0.01 points.The mean EQ-5D-5L score was(0.92±0.15).The multivariate linear regression analyses showed that increased bilirubin level(β=-0.009,P=0.018),increased CRP level(β=-0.005,P<0.001),and increased PHQ-9 score(β=-0.008,P=0.014)were negatively correlated with the EQ-5D-5L health utility value.Increased 6-MWD(β=0.005,P=0.018)was positively correlated with the EQ-5D-5L health utility value.Conclusion The bilirubin and CRP levels,depression status,and exercise capacity are considered the main factors influencing HRQOL in PD patients.

关 键 词：健康相关生活质量 EQ-5D-5L 运动耐量 腹膜透析 

分 类 号：R692.5[医药卫生—泌尿科学]