STEMI患者血清脂蛋白a及血浆纤维蛋白原的表达水平及对PCI术后近期预后的影响  

Expression Levels of Serum Lipoprotein A and Plasma Fibrinogen in Patients with STEMI and its Effect on Short-term Prognosis after PCI

作　　者：宋荣刚[1] 任静 金昭 SONG Ronggeng;REN Jing;JIN Shao(Department of Cardiology,the Fifth People's Hospital of Jinan,Jinan Shandong 250022;The First Ward of Binzhou Special Care Hospital,Binzhou,Shandong,256600)

机构地区：[1]济南市第五人民医院心内科,山东济南250022 [2]滨州市优抚医院一病区,山东滨州256600

出　　处：《智慧健康》2023年第29期42-46,共5页Smart Healthcare

摘　　要：目的 探究与分析急性ST段抬高型心肌梗死(ST-elevation myocardial infarction, STEMI)患者血清脂蛋白a及血浆纤维蛋白原的表达水平及对经皮冠状动脉动脉介入(percutaneous coronary intervention,PCI)术后近期预后的影响。方法 选取2019年5月—2022年2月本院收治的STEMI患者作为STEMI组(n=178),另选择非ST段抬高型心肌梗死(Non ST segment elevation myocardial infarction,NSEEMI)组(n=160)、不稳定型心绞痛组(n=150)以及对照组(n=140),对比四组人员的一般资料、血脂指标,血清脂蛋白a及血浆纤维蛋白原的表达水平。STEMI组按照血清脂蛋白a及血浆纤维蛋白原的表达水平高低分组,对比不同亚组下行PCI治疗术后的近期预后表现。结果 STEMI组、NSTEMI组、不稳定型心绞痛组与对照组相比高密度脂蛋白胆固醇(high density lipoprotein cholesterol, HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholestero, LDL-C)均较高,差异有统计学意义(P<0.05)。STEMI组、NSTEMI组、不稳定型心绞痛组与对照组相比血清脂蛋白a表达水平、血浆纤维蛋白原的表达水平均较高,STEMI组、NSTEMI组与不稳定型心绞痛组相比血清脂蛋白a表达水平、血浆纤维蛋白原的表达水平均较高,STEMI组与NSTEMI组相比血清脂蛋白a、血浆纤维蛋白原的表达水平较高,差异有统计学意义(P<0.05)。Ⅳ组与Ⅲ组相比,Ⅱ组与Ⅰ组相比PCI治疗术后的近期预后表现较差,差异有统计学意义(P<0.05)。结论 血清脂蛋白a及血浆纤维蛋白原在STEMI患者可呈现出异常升高的高表达水平,同时也可对PCI术后近期预后带来不良影响。Objective To explore and analyze acute ST-elevation myocardial infarction(ST-Elevation myocardial infarction),The expression levels of serum lipoprotein a and plasma fibrinogen in patients with STEMI and their effects on the short-term prognosis after Percutaneous coronary intervention(PCI).Methods STEMI patients admitted to our hospital from May 2019 to February 2022 were selected as STEMI group(n=178).Non-ST segment elevation myocardial infarction(NSEEMI)group(n=160),unstable angina pectoris group(n=150)and control group(n=140)were also selected.The general information,blood lipid index,serum lipoprotein a and plasma fibrinogen expression levels of the four groups were compared.STEMI group was divided according to the expression levels of serum lipoprotein a and plasma fibrinogen,and the short-term prognosis of different subgroups after PCI was compared.Results STEMI group,NSTEMI group and unstable angina group were compared with control group,High Density Lipoprotein Cholesterol,HDL-C was higher and Low Density Lipoprotein cholesterol(LDL-C)was higher,the difference was statistically significant(P<0.05).Compared with the control group,STEMI group,NSTEMI group and unstable angina group had higher serum lipoprotein a expression level and plasma fibrinogen expression level,STEMI group and NSTEMI group had higher serum lipoprotein a expression level and plasma fibrinogen expression level,compared with unstable angina group.The expression levels of serum lipoprotein a and plasma fibrinogen in STEMI group were higher than those in NSTEMI group,and the differences were statistically significant(P<0.05).The short-term prognosis of group IV and group II after PCI was worse than that of group IlI,and the difference was statistically significant(P<0.05).Conclusion The expression of serum lipoprotein a and plasma fibrinogen may be abnormally elevated in STEMI patients,which may also adversely affect the short-term prognosis after PCI.

关 键 词：经皮冠状动脉动脉介入术 急性ST段抬高型心肌梗死 血脂 血清脂蛋白A 血浆纤维蛋白原 

分 类 号：R542.22[医药卫生—心血管疾病]