脂肪酸氧化和促分解脂质介质水平与阴茎勃起功能障碍的相关性研究  

A study on the correlation between levels of fatty acid oxidation and lipolytic mediators and penile erectile dysfunction

作　　者：阿不来提·买买提明[1] 许鹏[1] 艾热提·阿皮孜[1] 艾沙江·阿卜力 李晓东[1] Abuliti Maimaitiming;Xu Peng;Aireti Apizi;Aishajiang Abuli;Li Xiaodong(Urology Center of the First Affiliated Hospital of Xinjiang Medical University,Xinjiang Province,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院泌尿中心,乌鲁木齐830054

出　　处：《疑难病杂志》2024年第2期217-221,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：新疆维吾尔自治区自然科学基金项目(2022D01C782)。

摘　　要：目的探究脂肪酸氧化和促分解脂质介质水平与阴茎勃起功能障碍的相关性。方法选取2022年10月—2023年4月新疆医科大学第一附属医院泌尿中心诊治的勃起功能障碍患者70例作为观察组,另外选取同期健康男性70例作为健康对照组。比较2组受试者一般临床资料、血清睾酮(T)、勃起硬度评分(EHS)、阴茎单侧动脉最大收缩期血流速度(PSV)、血清过氧化脂质(LPO)、消退素D1(RvD1)及消退素E1(RvE1)的表达水平。通过相关性分析、多因素Logistic回归分析筛选勃起功能障碍发生的危险因素。进一步通过受试者工作特征曲线(ROC)及曲线下面积(AUC)评价各危险因素对勃起功能障碍发生的预测价值。结果观察组患者血清LPO显著高于健康对照组(t/P=8.714/<0.001),RvD1、RvE1及EHS评分、PSV水平均显著低于健康对照组(t/P=10.109/<0.001、10.410/<0.001、6.271/<0.001、13.243/<0.001);Pearson相关性分析表明,血清LPO水平与EHS、PSV呈负相关(r/P=-0.275/0.033、-0.233/0.049),RvD1及RvE1水平与EHS、PSV呈正相关(r/P=0.391/<0.001、0.366/<0.001、0.423/<0.001、0.387/<0.001);多因素Logistic回归分析表明,血清LPO水平升高是勃起功能障碍发生的独立危险因素[OR(95%CI)=1.127(1.045~1.216)],RvD1及RvE1水平升高均是勃起功能障碍发生的保护因素[OR(95%CI)=0.761(0.669~0.866)、0.787(0.707~0.876)];ROC曲线分析表明,血清LPO、RvD1及RvE1预测勃起功能障碍发生的效能均较高,三者联合预测疾病的价值高于各指标独立预测价值(Z/P=1.873/0.013、1.803/0.019、1.711/0.033)。结论血清脂肪酸氧化水平增高、促分解脂质介质水平降低是勃起功能障碍发生的危险因素,为进一步探究勃起功能障碍的发生、发展机制提供新的思路。Objective To explore the correlation between levels of fatty acid oxidation and pro lipolytic mediators and penile erectile dysfunction.Methods Seventy patients with erectile dysfunction treated at the Urology Center of the First Affiliated Hospital of Xinjiang Medical University from October 2022 to April 2023 were selected as the observation group,and an additional 70 healthy males during the same period were selected as the healthy control group.Compare the general clinical data,serum testosterone(T),erectile hardness score(EHS),maximum systolic blood flow velocity(PSV)of unilateral penile artery,serum lipid peroxidation(LPO),expression levels of vasopressin D1(RvD1)and vasopressin E1(RvE1)between two groups of subjects.Screening for risk factors for erectile dysfunction through correlation analysis and multivariate logistic regression analysis.Further evaluate the predictive value of various risk factors for the occurrence of erectile dysfunction through receiver operating characteristic curve(ROC)and area under curve(AUC).Results The average serum LPO of the observation group patients was significantly higher than that of the healthy control group(t/P=8.714/<0.001),while RvD1,RvE1,EHS scores,and PSV levels were significantly lower than those of the healthy control group(t/P=10.109/<0.001,10.410/<0.001,6.271/<0.001,13.243/<0.001);Pearson correlation analysis showed that serum LPO levels were negatively correlated with EHS and PSV(r/P=-0.275/0.033,-0.233/0.049),while RvD1 and RvE1 levels were positively correlated with EHS and PSV(r/P=0.391/<0.001,0.366/<0.001,0.423/<0.001,0.387/<0.001);Multivariate logistic regression analysis showed that elevated serum LPO levels were independent risk factors for the occurrence of erectile dysfunction[OR(95%CI)=1.127(1.045-1.216)],and elevated levels of RvD1 and RvE1 were protective factors for the occurrence of erectile dysfunction[OR(95%CI)=0.761(0.669-0.866),0.787(0.707-0.876)];ROC curve analysis shows that serum LPO,RvD1,and RvE1 have high predictive power for the occurr

关 键 词：勃起功能障碍 脂肪酸氧化 促分解脂质介质 血管内皮 

分 类 号：R698.1[医药卫生—泌尿科学]