肠道微生物菌群与川崎病关系研究进展  

Research progress on relationship between gut microbiota and Kawasaki disease

作　　者：赵萌[1] 杨轶童 李翰文 孙文婷 赵苗苗 陈露萍 石曌玲 ZHAO Meng;YANG Yitong;LI Hanwen;SUN Wenting;ZHAO Miaomiao;CHEN Luping;SHI Zhaoling(Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学第二附属医院,陕西咸阳712044

出　　处：《陕西医学杂志》2024年第2期270-273,281,共5页Shaanxi Medical Journal

基　　金：国家自然科学基金资助项目(82205188);陕西省自然科学基础研究计划项目(2019JQ-544)。

摘　　要：川崎病(KD)是一种以全身血管炎为主要病变的急性发热出疹性小儿疾病,其发病机制尚未完全明确,但越来越多的证据表明肠道微生物菌群在其中起着重要作用。研究发现KD患者的肠道微生物菌群存在明显的异常。通过使用宏基因组学和代谢组学等技术,发现KD患者的肠道微生物菌群多样性降低,某些菌种如双歧杆菌属和乳杆菌属等的数量明显减少,而梭菌属等机会致病菌的数量增加。这些变化不仅与患者的病情严重程度相关,而且还影响了患者的免疫系统和代谢过程。越来越多的证据表明肠道微生物菌群可以通过调节免疫应答来影响KD的发生和发展。现就肠道微生物菌群与KD相关性研究进行综述。Kawasaki disease(KD)is an acute febrile exanthematous pediatric illness characterized by systemic vasculitis,and the pathogenesis is not fully understood.However,increasing evidence indicates that gut microbiota plays an important role.Studies have found significant abnormalities in the gut microbiota of patients with KD.Using techniques such as metagenomics and metabolomics,it was found that the diversity of gut microbiota in patients with KD is reduced,and the numbers of certain bacteria such as bifidobacterium and lactobacillus are significantly decreased,while the numbers of opportunistic pathogens such as clostridium are increased.These changes are not only associated with the severity of the disease but also affect the immune system and metabolic processes of the patient.There is increasing evidence that gut microbiota can regulate immune responses and affect the occurrence and development of KD.This article reviews the research on the correlation between gut microbiota and KD.

关 键 词：川崎病 肠道菌群 发病机制 免疫应答 全身炎性反应 信号通路 

分 类 号：R725.4[医药卫生—儿科]