颅内外动脉支架术后患者阿司匹林、氯吡格雷抵抗的相关因素研究  

Related Factors Study of Aspirin And Clopidogrel Resistance of Patients After Intracranial And Extracranial Artery Stenting Surgery

作　　者：蔡秀曲 戴永武 吕小红 唐劭年 李江 颜津津 CAI Xiuqu;DAI Yongwu;LV Xiaohong;TANG Shaonian;LI Jiang;YAN Jinjin(Guangzhou Medical University Affiliated Huizhou Hospital(Huizhou City the Third People's Hospital),Huizhou,Guangdong 516000;Longmen County People's Hospital,Huizhou,Guangdong 516878)

机构地区：[1]广州医科大学附属惠州医院/惠州市第三人民医院,广东惠州516000 [2]龙门县人民医院,广东惠州516878

出　　处：《智慧健康》2023年第27期100-104,共5页Smart Healthcare

基　　金：惠州市科技计划项目《颅内外动脉支架术后患者阿司匹林、氯吡格雷抵抗的相关因素研究》(项目编号:2021WC0106155)。

摘　　要：目的研究颅内外动脉支架术后患者氯吡格雷抵抗、阿司匹林抵抗的影响因素。方法从本院内颅内外动脉支架术后患者中抽取100例,收集2019年7月—2022年7月在本院神经内科颅内外动脉支架植入术后的患者,使用阿司匹林100mg+氯吡格雷75mg抗血小板药物1周检测血栓弹力图,根据AA抑制率结果将患者分为阿司匹林敏感组(n=60)、阿司匹林抵抗组(n=40),依据ADP抑制率结果分为氯吡格雷敏感组(n=70)、氯吡格雷抵抗组(n=30),统计分析患者基础资料及临床实验室参数指标,分析阿司匹林、氯吡格雷抵抗的影响因素。结果针对患者一般资料分析发现,年龄、性别、糖尿病、高血压、BMI均对于患者阿司匹林抵抗、氯吡格雷抵抗会产生一定影响(P<0.05)。实验室参数影响单因素分析发现,血小板体积、糖化血红蛋白指标差异明显(P<0.05)。结论颅内外动脉支架术后患者阿司匹林、氯吡格雷抵抗与年龄、性别、糖尿病、高血压、BMI有关,血小板体积、糖化血红蛋白属于阿司匹林、氯吡格雷抵抗的危险因素。Objective To study influencing factors of clopidogrel and aspirin resistance of patients after intracranial and extracranial artery stenting.Methods The paper chose 100 patients with intracranial and extracranial artery stent implantation in our hospital from July 2019 to July 2022,detected thromboelastogram after taking aspirin 100mg and clopidogrel 75mg antiplatelet drugs for one week.Patients were divided into aspirin sensitive group(n=60)and aspirin resistant group(n=40)based on AA inhibition rate results.patients were divided into clopidogrel sensitive group(n=70)and clopidogrel resistant group(n=30)based on results of ADP inhibition rate.Basic patient data and clinical laboratory parameters were statistically analyzed,influencing factors of aspirin and clopidogrel resistance were analyzed.Results:General data analysis of patients showed,age,gender,diabetes,hypertension,BMI all had some certain effect on aspirin resistance and clopidogrel resistance of patients(P<0.05).Single factor analysis of laboratory parameters showed significant difference in platelet volume and glycated hemoglobin indicators(P<0.05).Conclusion Aspirin and clopidogrel resistance of patients after extracranial and intracranial artery stenting is related to age,gender,diabetes,hypertension and BMI.Platelet volume and glycosylated hemoglobin is risk factor for aspirin and clopidogrel resistance.

关 键 词：颅内外动脉支架术 氯吡格雷 抵抗 阿司匹林 影响因素 

分 类 号：R651.1[医药卫生—外科学]