Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing  

作　　者：Jun Zhang Xingmei Chen Jingseng Lin Pei Zhang Iek Man Lei Yue Tao Jiajun Zhang Tian Luo Ji Liu 

机构地区：[1]Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen 518055,China [2]Research and Innovation Center,SKG Health Technology,Shenzhen 518000,China [3]SAFE(Shenzhen)Medical Technology Company Limited,Shenzhen 518000,China [4]Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen 518055,China [5]Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities,Southern University of Science and Technology,Shenzhen 518055,China

出　　处：《Nano Research》2024年第2期778-787,共10页纳米研究（英文版）

基　　金：support by Natural Science Foundation of Guangdong Province(Nos.2022A1515010152 and 2021A1515110735);the Basic Research Program of Shenzhen(Nos.JCYJ20210324105211032 and GJHZ20210705141809030);the Scientific Research Platforms and Projects of University of Guangdong Provincial Education Office(No.2022ZDZX3019);supported in part by the Science,Technology,and Innovation Commission of Shenzhen Municipality(No.ZDSYS20200811143601004).

摘　　要：Repairing Achilles tendon has emerged as a long-standing challenge in the orthopaedic surgeries.Although suture is the gold standard for re-attaching and repairing the fractured Achilles tendons in clinical surgeries,it is still subjected to numerous adverse side-effects,including chronic inflammatory,tendon tissue re-rupture,scar formation,and post-surgical peritendinous adhesion.In this work,we develop a class of hydrogel bioadhesives with tailored nanoscale phase separation for Achilles tendon repairing.To address the existing limitations of sutures,our hydrogel bioadhesives encompass three core functionalities:(i)instant and tough adhesion to Achilles tendon tissues,(ii)extraordinary long-term adhesion robustness under wet and dynamic in vivo conditions,and(iii)anti-postsurgical peritendinous adhesion.Combining our hydrogel bioadhesives with sutures,such kind of integrated approach enables a conformable yet robust biointerface with the tendon tissues,and prevents the fibroblast migration and formation of connective tissues,thus facilitating the tendon repairing.The hydrogel bioadhesives reported here open up new opportunities for the repairing of fractured Achilles tendons in diverse and complicated clinical scenarios.

关 键 词：HYDROGELS phase separation BIOADHESION ROBUSTNESS tendon repairing 

分 类 号：TB383[一般工业技术—材料科学与工程] TQ427.26[化学工程]