酞菁铜催化的8-氨基喹啉选择性C(sp^(2))-O偶联反应  

Copper(Ⅱ)phthalocyanine-catalyzed selective C(sp^(2))-O cross-coupling reactions of 8-aminoquinoline

作　　者：齐浩然 曹贝 曹敏 王凯 QI Haoran;CAO Bei;CAO Min;WANG Kai(College of Medical Engineering,Jining Medical University,Jining 272067,China;Medical Laboratory Department of Jining First People′s Hospital,Jining 272011,China)

机构地区：[1]济宁医学院医药工程学院,济宁272067 [2]济宁市第一人民医院医学检验科,济宁272011

出　　处：《济宁医学院学报》2024年第1期1-4,共4页Journal of Jining Medical University

基　　金：济宁医学院大学生创新训练计划(CX20220352)。

摘　　要：目的开发一种应用非均相催化体系的8-氨基喹啉衍生物选择性C-O键构建方法。方法分别从催化剂及氧化剂等对反应进行优化,并以筛选出的最优条件展开底物普适性考察。结果以酞菁铜作为催化剂,碘苯二乙酸为氧化剂,于50℃下在乙酸中反应5h,高效实现了8-氨基喹啉C5-H选择性C-O键构建。结论成功开发了一种应用非均相催化体系的C-O键构建方法并将其应用于8-氨基喹啉C5-H选择性官能团化。Objective Developing a heterogeneous catalysis system for the selective C5(sp^(2))-O cross coupling of 8-aminoquinoline derivatives.Methods Optimizing the reaction from catalysts and oxidants,the scope of substrates was then investigated via the optimal conditions.Results With copper phthalocyanine as catalyst and PhI(OAC)_(2) as oxidant,C5 selective C-O bond was efficiently constructed in AcOH at 50℃for 5h.Conclusion A method for C-O bond construction by means of heterogeneous catalytic system was successfully developed and applied to the selective functionalization of 8-aminoquinoline derivatives.

关 键 词：非均相催化 酞菁铜 8-氨基喹啉 C-O偶联反应 

分 类 号：O621.3[理学—有机化学]