欧洲医药保健网分类系统在甲氨蝶呤个体化用药相关问题的应用  

Application of pharmaceutical care network Europe classification system to methotrexate-related individual problems

作　　者：蔺婷婷 马静[1] 孙绍伟[1] 董宁霞[1] 魏传梅[1] 吕文文[1] 满玉清[1] LIN Tingting;MA Jing;SUN Shaowei;DONG Ningxia;WEI Chuanmei;LYU Wenwen;MAN Yuqing(Department of Pharmacy,Binzhou Medical University Hospital,Binzhou 256603,Shandong,P.R.China)

机构地区：[1]滨州医学院附属医院药学部,山东滨州256603

出　　处：《滨州医学院学报》2024年第1期32-35,共4页Journal of Binzhou Medical University

基　　金：山东省医学会临床科研专项资金(YXH20192X011);滨州医学院科研计划(BY2019KJ03)。

摘　　要：目的应用欧洲医药保健网(PCNE)分类系统对应用甲氨蝶呤(MTX)患者个体化用药中的药物相关问题(DRPs)进行分析探讨,为规范化个体化药学服务提供参考。方法以MTX用药后进行血药浓度测定和基因监测的患者为研究对象,采用PCNE分类系统(9.1版)分析MTX的DRPs,并对存在DRPs的问题、原因、介入干预以及接受程度进行分析。结果本研究共117例患者的738例次MTX的药学服务,发现244例次发生或潜在发生DRPs,85.25%进行了介入干预,介入干预接受208例次,接受率为73.56%。其中(可能)发生药品不良事件(n=188,77.05%)为DRPs常见问题,一个问题可能有多个原因,其中不适当的组合(27.08%)为主要原因。结论PCNE分类系统的引入有助于在MTX的个体化用药中实现药学服务的标准化,建立完善的精准药学服务体系,提升药学服务能力,促进合理用药。Objective To explore the application of the Pharmaceutical Care Network Europe(PCNE)classification system for drug-related problems(DRPs)in the individualized pharmacy of blood concentration monitoring and genetic testing,so as to provide basis for standardized individualized pharmacy services.Methods The DRPs of methotrexate were analyzed using the PCNE classification system(version 9.1)in patients undergoing methotrexate blood concentration as well as genetic monitoring,and the presence of DRPs,causes,intervention interventions,and acceptance were analyzed.Results In the present study,out of a total of 738 methotrexate visits to the pharmacy service in 117 patients,244 drug-related problems were identified,85.25%of which were intervened,with 208 intervention acceptances,giving an intervention acceptance rate of 73.56%.These(probable)adverse drug events(n=188,77.05%)were DRP FAQs,and one problem could have multiple causes,with inappropriate combination of drugs(27.08%)as the main cause.Conclusion The introduction of the PCNE classification system helps to standardize pharmacy services in the individualized administration of methotrexate,establish a perfect precision pharmacy service system,enhance the pharmacy service capacity,and promote the rational use of medication.

关 键 词：欧洲医药保健网 药物相关问题 甲氨蝶呤 血药浓度监测 基因多态性 药学服务 

分 类 号：R969.3[医药卫生—药理学]