microRNA-124在阿尔兹海默症中的作用及针刺干预研究进展  

Research progress on the role of microRNA-124 in Alzheimer’s disease and acupuncture intervention

作　　者：陈曦[1,2] 李玉姣 赵岚 CHEN Xi;LI Yujiao;ZHAO Lan(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381

出　　处：《天津中医药大学学报》2024年第1期64-70,共7页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82074533)。

摘　　要：阿尔兹海默症(AD)是老年人常见的神经退行性疾病。目前认为AD的病因大多与大脑中β-淀粉样蛋白(Aβ)的异常沉积、相关蛋白Tau的过度磷酸化以及各种细胞因子、补体的释放有关。microRNA-124在中枢神经系统中高度表达,与许多神经生理和病理过程相关。microRNA-124通过Aβ沉积、Tau蛋白过度磷酸化、神经炎症、氧化应激、神经元兴奋性和神经分化等多种方式在AD中发挥作用。它还可能通过调节细胞凋亡对突触可塑性和轴突生长产生不利影响,进而影响AD。因此,探讨microRNA-124在AD中的表达变化以及靶向治疗至关重要。针刺治疗AD疗效明确,可能与microRNA-124调控相关。文章就AD所具有的几个典型组织病理学特征与microRNA-124的相关性进行综述,包括老年斑中Aβ的积累、Tau过度磷酸化、神经炎症和突触丧失。综述了microRNA-124通过靶向不同的基因与调节下游信号在AD中发挥作用,以及针刺治疗AD的可能干预机制,为未来治疗提供新思路。Alzheimer’s disease(AD)is a common neurodegenerative disease of the elderly.The etiology of AD is now mostly thought to be related to abnormal deposition of Aβin the brain,hyperphosphorylation of the related protein Tau,and release of various cytokines and complement.microRNA-124 is highly expressed in the central nervous system and is associated with many neurophysiological and pathological processes.microRNA-124 functions in AD in a variety of ways through Aβdeposition,Tau protein hyperphosphorylation,neuroinflammation,oxidative stress,neuronal excitability,and neural differentiation.It may also adversely affect synaptic plasticity and axonal growth by regulating apoptosis,which in turn affects AD.Therefore,it is crucial to explore the changes in microRNA-124 expression in AD and targeting therapy.The clear efficacy of acupuncture in treating AD may be related to microRNA-124 modulation.In this paper,we review the relevance of microRNA-124 to several typical histopathological features possessed by AD,including Aβaccumulation in age spots,Tau hyperphosphorylation,neuroinflammation,and synaptic loss.The role of microRNA-124 in AD through targeting different genes as well as regulating downstream signaling and the possible intervention mechanisms of acupuncture for AD are reviewed to provide new ideas for future treatment.

关 键 词：阿尔兹海默症 microRNA-124 针刺 神经炎症 突触可塑性 

分 类 号：R245[医药卫生—针灸推拿学]