生殖免疫抗体检测在女性不孕不育生殖道感染中的应用价值  

Application of reproductive immune antibody detection on female infertility with reproductive tract infection

作　　者：段红伟 孙丽丽 王晓滇 李丽娟 范红云 DUAN Hongwei;SUN Lili;WANG Xiaodian;LI Lijuan;FAN Hongyun(Department of Obstetrics and Gynecology,Zhengzhou Longhai Hospital,Zhengzhou 450004,China;Department of Obstetrics and Gynecology,Zhengzhou Shengma Maternity Hospital,Zhengzhou 450007,China;Department of Obstetrics and Gynecology,Zhengzhou Tianlun Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州陇海医院妇产科,河南郑州450004 [2]郑州圣马妇产医院妇产科,河南郑州450007 [3]郑州天伦医院妇产科,河南郑州450003

出　　处：《宁夏医学杂志》2024年第1期57-60,I0001,共5页Ningxia Medical Journal

摘　　要：目的 检测血清生殖免疫抗体,分析其在不孕不育女性生殖道感染中的应用价值。方法 回顾性分析136例不孕不育症育龄期女性临床资料,其中合并生殖道感染74例(感染组),无生殖道感染62例(未感染组)。比较2组血清抗精子抗体(ASAb)、抗子宫内膜抗体(EMAb)、抗卵巢抗体(AOAb)、抗心磷脂抗体(ACAb)水平差异,使用受试者工作特征(ROC)曲线评估血清ASAb、EMAb、AOAb、ACAb对不孕不育症合并生殖道感染的诊断效能,并记录不同病原感染者血清ASAb、EMAb、AOAb、ACAb检测结果。结果 感染组血清ASAb、EMAb、AOAb、ACAb阳性率及血清含量明显高于未感染组(P<0.05)。ROC曲线分析显示,血清ASAb、EMAb、AOAb、ACAb诊断不孕不育症合并生殖道感染的AUC值分别为0.972、0.945、0.968、0.862(P<0.05)。感染组中,不同病原感染者血清ASAb、EMAb、AOAb、ACAb阳性率比较差异无统计学意义(P>0.05)。结论 ASAb、EMAb、AOAb、ACAb对女性不孕不育症合并生殖道感染具有较高诊断效能,临床应用价值较高。Objective To explore the application value of reproductive immune antibody detection on female infertility with reproductive tract infection.Methods The clinical data of 136 women with infertility of childbearing age were retrospectively analyzed,including 74 cases with reproductive tract infection(infection group)and 62 cases without reproductive tract infection(non-infection group).The differences in detection status of serum antisperm antibody(ASAb),endometrial antibody(EMAb),anti-ovarian antibody(AOAb)and anticardiolipin antibody(ACAb)were compared between two groups,and the receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficiency of serum ASAb,EMAb,AOAb and ACAb on infertility with reproductive tract infection,and the detection status of serum ASAb,EMAb,AOA and ACAb were recorded among patients with different pathogen infections.Results The positive rates and levels of serum ASAb,EMAb,AOAb and ACAb in infection group were significantly higher than those in non-infection group(P<0.05).ROC curve analysis revealed that the AUC values of serum ASAb,EMAb,AOAb and ACAb in the diagnosis of infertility with reproductive tract infection were respectively 0.972,0.945,0.968 and 0.862(P<0.05).In infection group,there were no statistically significant differences in the positive expression rates of serum ASAb,EMAb,AOAb and ACAb among patients with different pathogen infections(P>0.05).Conclusion ASAb,EMAb,AOAb and ACAb have high diagnostic efficiency on female infertility with reproductive tract infection and have high clinical application value.

关 键 词：不孕不育症 生殖道感染 生殖免疫抗体 血清抗精子抗体 抗子宫内膜抗体 抗卵巢抗体 抗心磷脂抗体 

分 类 号：R711.6[医药卫生—妇产科学]