尿道结石梗阻合并肾积水患者的尿液细菌分布及药敏试验结果分析  

Analysis of Urinary Bacterial Distribution and Drug Sensitivity Test Results in Patients with Urethral Stone Obstruction and Hydronephrosis

作　　者：刘琼章 温成波 李方方 LIU Qiongzhang;WEN Chengbo;LI Fangfang(Chashan Hospital of Dongguan,Guangdong Dongguan 523380)

机构地区：[1]东莞市茶山医院,广东东莞523380

出　　处：《深圳中西医结合杂志》2023年第22期19-22,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:分析尿道结石梗阻合并肾积水患者的尿液细菌分布及药敏试验结果,为临床治疗提供一定的参考依据。方法:选择2021年5月至2023年8月期间东莞市茶山医院泌尿外科收治的尿道结石梗阻合并肾积水患者70例为研究对象。所有患者均进行尿液收集,在无菌环境下对病原菌进行培养,并进行药敏试验,记录细菌分布情况及药敏试验结果。结果:尿道结石梗阻合并肾积水患者共分离出70株病原菌,革兰阴性菌50株(占71.43%),革兰阳性菌16株(占22.86%),其他菌4株(占5.71%)。检出的病原菌占比较多的为大肠埃希菌30株(42.86%)、奇异变形杆菌9株(12.86%)、肺炎克雷伯菌肺炎亚种6株(8.57%)、粪肠球菌4株(5.71%)、无乳链球菌4株(5.71%)。大肠埃希菌对亚胺培南、厄他培南、替加环素的耐药率达到100.00%,奇异变形菌和肺炎克雷伯菌肺炎亚种对大部分抗菌药物的耐药率超过50.00%,粪肠球菌对红霉素耐药达到100.00%,无乳链球菌对大多数抗菌药物的耐药率均在50.00%及以上。结论:尿道结石梗阻合并肾积水患者致病菌种类较多,且不同致病菌对多种抗菌药物的耐药性存在显著差异。临床治疗过程中,应注意评估患者病原菌的易感性,根据耐药性的高低,选择合适的抗菌药物。Objective To analyze the distribution of urinary bacteria and drug sensitivity test results in patients with urethral stone obstruction combined with hydronephrosis,and provide a certain reference basis for clinical treatment.Methods A total of 70 patients with urethral stone obstruction and hydronephrosis admitted to the department of urology at Chashan Hospital of Dongguan from May 2021 to August 2023 were selected as the study subjects.All patients underwent urine collection and pathogenic bacteria were cultured in a sterile environment,followed by drug sensitivity tests.The distribution of bacteria and drug sensitivity test results were recorded.Results A total of 70 pathogenic bacteria were isolated from patients with urethral stone obstruction and hydronephrosis,including 50 Gram negative bacteria(71.43%),16 Gram positive bacteria(22.86%),and 4 other bacteria(5.71%).The majority of detected pathogens were Escherichia coli in 30(42.86%),Proteus mirabilis in 9(12.86%),Klebsiella pneumoniae in 6(8.57%),Enterococcus faecalis in 4(5.71%),and Streptococcus agalactiae in 4(5.71%).Escherichia coli has a resistance rate of 100.00%to imipenem,ertapenem,and tigecycline,while Proteus mirabilis and Klebsiella pneumoniae subspecies pneumonia have a resistance rate of over 50.00%to most antibiotics.Enterococcus faecalis has a resistance rate of 100.00%to erythromycin,and Streptococcus agalactiae has a resistance rate of over 50.00%to most antibiotics.Conclusion There are many types of pathogenic bacteria in patients with urethral stone obstruction and hydronephrosis,and there are significant differences in the resistance of different pathogenic bacteria to various antibiotics.During clinical treatment,attention should be paid to evaluating the susceptibility of patients to pathogens and selecting appropriate antibiotics based on the level of drug resistance.

关 键 词：尿道结石梗阻 肾积水 尿液检验 

分 类 号：R378[医药卫生—病原生物学] R446.5[医药卫生—基础医学]