拮抗剂促排卵行新鲜周期移植不同黄体支持方案的效果比较  

Comparison of Effects of Different Luteal Support Schemes in Fresh Cycle Transplantation with Antagonist for Ovulation Promotion

作　　者：程婷婷[1] 王祁 CHENG Tingting;WANG Qi(Xuzhou Maternal and Child Health Hospital,Jiangsu Xuzhou 221000)

机构地区：[1]徐州市妇幼保健院,江苏徐州221000

出　　处：《深圳中西医结合杂志》2023年第22期111-114,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:比较拮抗剂促排卵行新鲜周期移植不同黄体支持方案的效果。方法:选取2019年1月至2021年3月于徐州市妇幼保健院采用拮抗剂方案促排卵行新鲜周期移植的80例不孕症患者作为研究对象,回顾性分析患者的临床资料,根据患者的不同黄体支持方案分为观察组与对照组。对照组予以孕激素+雌激素+促性腺激素释放激素类似物(GnRHa)方案进行黄体支持,共40例。观察组予以孕激素+雌激素+GnRHa+人绒毛膜促性腺激素(HCG)方案进行黄体支持,共40例。比较两组患者促排卵情况及胚胎发育情况、临床结局。结果:两组患者各项促排卵情况及胚胎发育情况比较,差异无统计学意义(P> 0.05)。观察组患者临床妊娠率、活产率高于对照组,异位妊娠率、流产率低于对照组,差异具有统计学意义(P <0.05)。两组患者多胎率比较,差异无统计学意义(P> 0.05)。结论:拮抗剂促排卵行新鲜周期移植后采用孕激素+雌激素+GnRHa+HCG方案进行黄体支持,可明显改善不孕症患者的临床妊娠率及活产率,改善患者的妊娠结局,是拮抗剂促排卵新鲜周期移植理想的黄体支持方案。Objective To compare the effects of different luteal support schemes in fresh cycle transplantation with antagonist for ovulation promotion.Methods A total of 80 infertility patients who underwent fresh cycle transplantation with antagonist regimen to promote ovulation in Xuzhou Maternal and Child Health Hospital from January 2019 to March 2021 were selected as the study objects.Clinical data of the patients were retrospectively analyzed,and they were divided into an observation group and a control group,with 40 cases in each group,according to different luteal support programs.The control group was given progesterone+estrogen+gonadotropin-releasing hormone analogue(GnRHa)regimen for luteal support.The observation group was given progesterone+estrogen+GnRHa+human chorionic gonadotropin(HCG)regimen for luteal support.Ovulation induction,embryo development and clinical outcome were compared between the two groups.Results There was no significant difference in ovulation promotion and embryo development between the two groups(P>0.05).The clinical pregnancy rate and live birth rate of the observation group were higher than those of the control group,while the ectopic pregnancy rate and abortion rate were lower than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the multiple birth rate between the two groups(P>0.05).Conclusion Progesterone+estrogen+GnRHa+HCG regimen for luteal support after fresh cycle transplantation with antagonist stimulating ovulation can significantly improve the clinical pregnancy rate and live birth rate of infertility patients,and improve the pregnancy outcome of patients,which is an ideal luteal support regimen for fresh cycle transplantation with antagonist stimulating ovulation.

关 键 词：不孕症 拮抗剂方案 促排卵 新鲜周期移植 黄体支持方案 

分 类 号：R271.14[医药卫生—中医妇科学]