常州市老年肺结核患者利福平耐药分析  

Rifampicin resistance among elderly patients with pulmonary tuberculosis in Changzhou City

作　　者：吴玉姣[1] 左小明[1] 秦科宇 张志新[2] 张兴[3] WU Yujiao;ZUO Xiaoming;QIN Keyu;ZHANG Zhixin;ZHANG Xing(Department of Pharmacy,Changzhou Third People's Hospital,Changzhou,Jiangsu 213000,China;Changzhou Third People's Hospital,Changzhou,Jiangsu 213000,China;Changzhou Center for Disease Control and Prevention,Control,Changzhou,Jiangsu 213000,China)

机构地区：[1]常州市第三人民医院药事科,江苏常州213000 [2]常州市第三人民医院,江苏常州213000 [3]常州市疾病预防控制中心,江苏常州213000

出　　处：《预防医学》2024年第2期162-164,168,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：常州市科技项目(CE20215019,CJ20239024);天晴医院药学基金项目(Q202145)。

摘　　要：目的 了解江苏省常州市老年肺结核患者利福平耐药情况及其影响因素,为完善耐药结核病防控策略提供依据。方法 选择2020—2022年在常州市结核病定点医院就诊的>60岁肺结核患者为研究对象,收集人口学信息、既往疾病与诊疗史、药敏试验等资料,分析老年肺结核患者利福平耐药情况及其影响因素。结果 共纳入249例老年肺结核患者,年龄为(69.75±4.36)岁。男性147例,女性102例,男女性别比为1.44∶1。初治患者183例,占73.49%;复治患者66例,占26.51%。利福平耐药21例,耐药率为8.43%。其中初治患者7例,耐药率为3.83%;复治患者14例,耐药率为21.21%。多因素logistic回归分析结果显示,老年肺结核复治患者利福平耐药风险较高(OR=10.551,95%CI:1.344~82.857)。结论 常州市249例老年肺结核患者利福平耐药率为8.43%,治疗类型是利福平耐药的影响因素。Objective To investigate the rifampicin resistance status and its influencing factors among elderly patients with pulmonary tuberculosis in Changzhou City,Jiangsu Province,so as to provide the basis for improving drug-resis⁃tant pulmonary tuberculosis prevention and control strategies.Methods Patients aged over 60 years with pulmonary tu⁃berculosis treated in tuberculosis designated hospital was selected.Demographic information,history of previous disease,history of diagnosis and treatment and drug sensitivity test were collected.Rifampicin resistance among elderly patients with pulmonary tuberculosis and its influencing factors was analyzed.Results Totally 249 elderly patients with pulmo⁃nary tuberculosis were included,with an average of(69.75±4.36)years.There were 147 males and 102 females,with a gender ratio of 1.44∶1.There were 183 treatment-naïve patients(73.49%)and 66 retreated patients(26.51%).Rifampi⁃cin resistance was found in 21 cases,with a drug resistance rate of 8.43%.Among them,there were 7 treatment-naïve patients(3.83%),and 14 retreated patients(21.21%).Multivariable logistic regression analysis showed that retreated el⁃derly patients with pulmonary tuberculosis had a higher risk of rifampicin resistance(OR=10.551,95%CI:1.344-82.857).Conclusion The rifampicin resistance rate of 249 elderly patients with pulmonary tuberculosis was 8.43%and was associated with the type of treatment.

关 键 词：老年人 肺结核 利福平耐药 影响因素 

分 类 号：R521[医药卫生—内科学]