基于文献数据挖掘中药外用治疗跟痛症用药规律研究  

Analysis of External Use of Traditional Chinese Medicine and Medication Law in Treatment of Calcaneodynia Based on Literature Data Mining

作　　者：吉富涛 尹本敬 陈葛[1] 程强 廖建青 郑太才 冉伟鹏 王琪 李具宝 JI Futao;YIN Benjing;CHEN Ge;CHENG Qiang;LIAO Jianqing;ZHENG Taicai;RAN Weipeng;WANG Qi;LI Jubao(Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;Yunnan Province Hospital of Traditional Chinese Medicine,Kunming 650021,China)

机构地区：[1]云南中医药大学,昆明650500 [2]云南省中医医院,昆明650021

出　　处：《世界中医药》2023年第23期3411-3417,共7页World Chinese Medicine

基　　金：国家自然科学基金项目(81860862、81460736);云南省中青年学术和技术带头人后备人才项目(云科人发〔2019〕7号);云南省高层次中医药人才学科带头人项目(云卫中医发展发〔2021〕1号);云南省卫生科技计划项目(2017NS161)。

摘　　要：目的:基于30年文献数据挖掘中药外用治疗跟痛症的用药规律,为跟痛症的辨证论治和遣方用药提供理论指导和参考依据。方法:运用国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)对中药外用治疗跟痛症的中文文献进行检索,构建跟痛症的外用中药数据库,通过对中药频次统计、相互关联规则分析、分层聚类分析等数据挖掘方法总结和分析高频次中药、核心药物及处方潜在规律。结果:中药外用治疗跟痛症排名前20位的主要是透骨草、红花、伸筋草、威灵仙、牛膝、川芎、川乌、桂枝、乳香、当归、草乌、没药、独活、海桐皮、苏木、木瓜、花椒、五加皮、防风、艾叶;在四气分布中使用频率最多的为温性中药,其次为平性和热性中药;在五味分布中使用最多的为辛味中药,其次为苦味和甘味中药;在归经分布中使用最多的前3位分别为肝、脾、肾经;在支持度设置为≥20%的基础上,将置信度设为≥80%,得到“白芍-当归”“没药-红花”等搭配规则的关联药物共27组;通过高频次中药的聚类分析得到核心药物组合共14组。结论:中药外用治疗跟痛症主要以补益肝肾、祛风除湿、活血化瘀为主。药性主要为温、平、热,药味主要为辛、苦、甘,归经主要为肝、脾、肾经。Objective:Based on the literature data of 30 years,the medication rules of external use of traditional Chinese medicine in the treatment of calcaneodynia were mined to provide theoretical guidance and reference for the treatment of calcaneodynia based on syndrome differentiation and prescriptions.Methods:China National Knowledge Infrastructure,China Science Periodical Database,Chinese Citation Database,and China Biology Medicine disc were used to search the Chinese literature on the external use of traditional Chinese medicine for the treatment of calcaneodynia,and the external use of traditional Chinese medicine database was constructed.Data mining methods such as frequency statistics,correlation rule analysis,and hierarchical clustering analysis were used to summarize and analyze high-frequency traditional Chinese medicine,core drugs,and potential rules of prescription.Results:The top 20 Chinese herbs for treating calcaneodynia by external use are as follows:Herba Speranskiae Tuberculatae,Flos Carthami,Herba Lycopodii,Radix Clematidis,Achyranthes Bidentata,Rhizoma Ligustici Chuanxiong,Radix Aconiti,Cinnamomum Cassia Presl,Olibanum,Angelica Sinensis,Radix Aconiti Kusnezoffii,Myrrh,Radix Angelicae Pubescentis,Cortex Erythrinae,Lignum Sappan,Chaenomeles Speciosa,Sichuan Pepper,Acanthopanacis cortex,Radix Saposhnikoviae,and Mugwort Leaves.The warm medicine of the four qi is used the most frequently,followed by Chinese herbal medicines of a flat and hot nature.In the distribution of five flavors,the most used Chinese herbal medicines are pungent flavors,followed by bitter and sweet Chinese medicines.In the distribution of meridians,the most used traditional Chinese medicines in the top three are the liver,spleen,and kidney meridians.According to the support degree of≥20%,the confidence level is set to≥80%,and a total of 27 groups of related drugs with the matching rules such as“Paeonia lactiflora Pall-Angelica Sinensis”and“myrrh-Flos Carthami”are obtained.A total of 14 groups of core drug combinations ar

关 键 词：跟痛症 中药 外用 功效 性味 归经 文献 数据挖掘 

分 类 号：R244.9[医药卫生—针灸推拿学] R274.9[医药卫生—中医临床基础]