GSK-3介导的信号通路在类风湿关节炎中的作用的研究进展  

Research progress on the role of GSK-3 mediated signaling pathway in rheumatoid arthritis

作　　者：陆婷 蒋总 兰维娅 唐芳 LU Ting;JIANG Zong;LAN Weiya;TANG Fang(Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550002,China;Department of Rheumatology and Immunology,The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550003,China)

机构地区：[1]贵州中医药大学,贵阳550002 [2]贵州中医药大学第二附属医院风湿免疫科,贵阳550003

出　　处：《重庆医学》2024年第3期451-455,共5页Chongqing medicine

基　　金：国家自然科学基金项目(82160917);贵州省中医药管理局中医药、民族医药科学技术研究项目(QZYY-2020-005);贵州省科技厅计划项目(黔科合基础-ZK[2023]一般435);贵州中医药大学研究生教育创新计划自然科学项目(YCXZRS202212)。

摘　　要：类风湿关节炎(RA)作为一种炎症性疾病,可导致多系统损伤,其中以关节损伤最为常见。RA的发病机制尚未明确,有研究表明,糖原合成酶激酶3(GSK-3)与RA的发展密切相关。GSK-3作为一种混杂的蛋白激酶,其不同底物的磷酸化对许多生理和病理产生重大影响,并在多种疾病中失调。GSK-3参与许多信号通路的调控,并通过不同的方式作用于RA。研究发现,GSK-3主要通过Wnt/β-连环蛋白(β-catenin)、磷酸酰肌醇3激酶(PI3K)/蛋白激酶B(Akt)、核因子-κB(NF-κB)3条信号通路在RA中发挥作用。该文就GSK-3与上述3条信号通路在RA中的发生、发展及作用做一综述。Rheumatoid arthritis(RA),as an inflammatory disease,can lead to multiple system damage,of which joint damage is the most common.The pathogenesis of RA is not yet clear.Studies have shown that glycogen synthetase kinase 3(GSK-3)is closely related to the development of RA.As a hybrid protein kinase,the phosphorylation of different substrates of GSK-3 has a significant impact on many physiology and pathology,and is dysregulated in a variety of disease.GSK-3 is involved in the regulation of many signaling pathways and acts on RA in different ways.Studies have found that GSK-3 plays a role in RA mainly through Wnt/β-catenin,PI3K/Akt and NF-κB signaling pathways.This article reviews the occurrence,development and role of GSK-3 and the above three signaling pathways in RA.

关 键 词：糖原合成酶激酶3 信号通路 类风湿关节炎 作用 

分 类 号：R593.22[医药卫生—内科学]