有氧运动对心力衰竭患者炎症因子水平影响的Meta分析  

Meta-Analysis of Effects of Aerobic Exercise on Inflammatory Factors in Patients with Heart Failure

作　　者：聂文鹏 张媛媛[1] 杨宏博 张敬 董波[1,2] 崔文竹 Nie Wenpeng;Zhang Yuanyuan;Yang Hongbo(Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东第一医科大学附属省立医院心内科,山东济南250021 [3]山东中医药大学第二附属医院,山东济南250001

出　　处：《四川医学》2024年第1期11-17,共7页Sichuan Medical Journal

基　　金：山东省中医药管理局基金(编号:2021Q105)。

摘　　要：目的探究有氧运动对心力衰竭患者炎症因子水平的影响。方法计算机检索中、英文数据库,获取发表时间为建库至2023年3月18日的关于有氧运动对心力衰竭患者炎症因子水平影响的随机对照研究,筛选检索到的文献并进一步提取数据,最终对纳入的文献进行质量评价。使用RevMan5.3软件进行Meta分析。结果最终纳入11篇研究,涉及618例患者,运动组315例,对照组303例。Meta分析结果显示,与对照组相比,有氧运动能更好地降低心力衰竭患者血浆CRP[RR=-1.26,95%CI(-2.28,-0.24),P=0.02]、hs-CRP[SMD=-1.68,95%CI(-2.00,-1.37),P<0.00001]、TNF-α[SMD=-0.57,95%CI(-0.81,-0.34),P<0.00001]、IL-6[SMD=-0.51,95%CI(-0.71,-0.31),P<0.00001],差异具有统计学意义(P<0.05)。结论有氧运动能够降低心力衰竭患者炎症因子水平,改善炎症状态。Objective To investigate the effect of aerobic exercise on inflammatory factors in patients with heart failure.Methods A computer-based search of Chinese and English databases was undertaken for randomized controlled studies on effects of aerobic exercise on inflammatory factors in patients with heart failure published until March 18,2023,after screening retrieved literature and further extracting data,quality of the included literature was finally evaluated.Meta-analysis was performed using RevMan 5.3 software.Results In the end,11 studies were included,involving 618 patients,315 in exercise group and 303 in control group.Results of Meta-analysis showed that aerobic exercise significantly reduced plasma CRP[RR=-1.26,95%CI(-2.28,-0.24),P=0.02],hs-CRP[SMD=-1.68,95%CI(-2.00,-1.37),P<0.0001],TNF-α[SMD=-0.57,95%CI(-0.81,-0.34),P<0.00001],IL-6[SMD=-0.51,95%CI(-0.71,-0.31),P<0.00001]with statistically significant differences(P<0.05).Conclusion Aerobic exercise could reduce inflammatory factors in patients with heart failure and improve inflammatory state.

关 键 词：有氧运动 心力衰竭 炎症 META分析 

分 类 号：R541.6[医药卫生—心血管疾病]