中药山茱萸治疗糖尿病肾病研究现状  

Research Status of Cornus officinalis in Treating Diabetic Nephropathy

作　　者：李璞琳 杨晨慧 谢绍锋[1] 黄莉吉[2] LI Pu-lin;YANG Chen-hui;XIE Shao-feng;HUANG Li-ji(The Third Clinical School of Nanjing University of Traditional Chinese Medicine/The Integrative Chinese and Western Medicine Hospital Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing 210028,China;The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学第三临床医学院/南京中医药大学附属中西医结合医院,江苏南京210028 [2]南京中医药大学附属医院,江苏南京210029

出　　处：《云南中医中药杂志》2023年第12期76-79,共4页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：江苏省中医药局科技项目(FY201706);江苏省中医药局科技项目(YB201910)。

摘　　要：山茱萸为常用中药材,补益肝肾,收涩固脱是其功效。山茱萸复方可以改善糖尿病肾病患者临床症状,降低尿蛋白排泄、改善肾功能等;其作用机制包括抑制肾组织白介素6(IL-6)等多种炎症因子分泌,抑制晚期糖基化终产物产生,减少肾小管上皮细胞中胆固醇积累,以及促进肾组织一氧化氮合成等。Cornus officinalis is a commonly used Chinese herbal medicine and has the effect of tonifying liver and kidney.Cornus officinalis compound can improve the clinical symptoms of diabetic nephropathy patients,reduce urinary protein excretion,improve renal function and so on.Its mechanism of action includes inhibiting the secretion of various inflammatory factors such as interleukin-6(IL-6)in renal tissue,inhibiting the production of advanced glycosylation end products,reducing the accumulation of cholesterol in renal tubular epithelial cells,and promoting the synthesis of nitric oxide in renal tissue.

关 键 词：山茱萸 糖尿病肾病 临床研究 作用机制 

分 类 号：R692[医药卫生—泌尿科学]