子宫肌瘤组织中MMP-2、MLCK、VEGF及IGF-2表达及其临床意义  

Expression and Clinical Significance of MMP-2,MLCK,VEGF,and IGF-2 in Uterine Fibroid Tissue

作　　者：蔡莉娜[1] 张庆[1] 屈红杰 CAI Lina;ZHANG Qing;QU Hongjie(Zhengzhou University Second Affiliated Hospital,Zhengzhou,450014)

机构地区：[1]郑州大学第二附属医院,450014

出　　处：《实用癌症杂志》2024年第2期194-196,共3页The Practical Journal of Cancer

摘　　要：目的分析基质金属蛋白酶-2(MMP-2)、肌球蛋白轻链激酶(MLCK)、血管内皮生长因子(VEGF)、胰岛素样生长因子-2(IGF-2)在子宫肌瘤组织内的表达及临床意义。方法选取76例子宫肌瘤患者,收集其子宫肌瘤组织及正常子宫组织,采用免疫组织化学法测定MMP-2、MLCK、VEGF及IGF-2表达,统计对比两者的阳性率。结果子宫肌瘤组织中MMP-2、MLCK、VEGF及IGF-2阳性表达率分别为69.74%(53/76)、60.53%(46/76)、81.58%(62/76)、92.11%(70/76),高于正常子宫组织的15.79%(12/76)、10.53%(8/76)、17.11%(13/76)、30.26%(23/76),差异有统计学意义(P<0.05)。结论MMP-2、MLCK、VEGF及IGF-2在子宫肌瘤组织中呈异常的高表达,与疾病的发生与发展存在紧密联系。Objective To analyze the expression and clinical significance of matrix metalloproteinase-2(MMP-2),myosin light chain kinase(MLCK),vascular endothelial growth factor(VEGF),and insulin-like growth factor-2(IGF-2)in uterine fibroids.Methods 76 patients with uterine fibroids were selected and their uterine fibroid tissue and normal uterine tissue were collected.The expression of MMP-2,MLCK,VEGF,and IGF-2 was measured using immunohistochemistry,and the positive rates of the two were statistically compared.Results The positive expression rates of MMP-2,MLCK,VEGF,and IGF-2 in uterine fibroids were 69.74%(53/76),60.53%(46/76),81.58%(62/76),and 92.11%(70/76),respectively,higher than 15.79%(12/76),10.53%(8/76),17.11%(13/76),and 30.26%(23/76)in normal uterine tissues,with statistically significant differences(P<0.05).Conclusion MMP-2,MLCK,VEGF,and IGF-2 are abnormally overexpressed in uterine fibroid tissue,which is closely related to the occurrence and development of the disease.

关 键 词：子宫肌瘤 基质金属蛋白酶-2 血管内皮生长因子 胰岛素样生长因子-2 

分 类 号：R737.33[医药卫生—肿瘤]