骨化三醇胶丸联合胰激肽原酶对2型糖尿病微血管并发症患者外周血Hcy、RBP4、SAA水平的影响  

Effects of calcitriol capsules combined with pancreatic kininogenase on levels of Hcy,RBP4 and SAA in peripheral blood of patients with microvascular complications of type 2 diabetes mellitus

作　　者：曾秀伟 尚士博 赵艳荣[1] 杨玲 ZENG Xiu-wei;SHANG Shi-bo;ZHAO Yan-rong(Department of Endocrinology,the Second Hospital of Qinhuangdao,Qinhuangdao Hebei 066600,China;Department of Digestive,the Second Hospital of Qinhuangdao,Qinhuangdao Hebei 066600,China)

机构地区：[1]秦皇岛市第二医院内分泌科,河北秦皇岛066600 [2]秦皇岛市第二医院消化科,河北秦皇岛066600 [3]秦皇岛市第二医院肿瘤科,河北秦皇岛066600

出　　处：《临床和实验医学杂志》2024年第1期36-41,共6页Journal of Clinical and Experimental Medicine

基　　金：秦皇岛市科学技术研究与发展计划(编号:201902A176)。

摘　　要：目的观察骨化三醇胶丸联合胰激肽原酶对2型糖尿病微血管并发症患者外周血同型半胱氨酸(Hcy)、视黄醇结合蛋白4(RBP4)、淀粉样蛋白A(SAA)水平的影响。方法前瞻性选取2020年1月至2022年12月秦皇岛市第二医院收治的104例2型糖尿病微血管并发症患者为对象,采用随机数字表法分为常规组(n=52)和骨化三醇组(n=52)。两组均接受利拉鲁肽治疗,常规组加用胰激肽原酶治疗,骨化三醇组在常规组基础上联合骨化三醇胶丸治疗。比较两组糖代谢(空腹血糖、餐后2 h血糖)、Hcy、RBP4、SAA、正五聚蛋白3(PTX3)及骨代谢指标[25-羟基维生素D(25(OH)D)、骨碱性磷酸酶(BAP)、骨保护素(OPG)、Ⅰ型前胶原氨基端延长肽(P1NP)、Ⅰ型前胶原氨基端延长肽(β-CTX)、碱性磷酸酶(ALP)]的水平差异,统计两组不良反应发生情况。结果治疗后,两组的空腹血糖、餐后2 h血糖均较治疗前降低,差异均有统计学意义(P<0.05);但骨化三醇组和常规组组间比较,差异均无统计学意义(P>0.05)。治疗后,骨化三醇组和常规组的Hcy、RBP4、SAA、PTX3水平均较治疗前降低,差异均有统计学意义(P<0.05),且骨化三醇组Hcy、RBP4、SAA、PTX3水平分别为(10.23±2.06)μmol/L、(32.85±5.15)mg/L、(23.01±3.86)μg/mL、(18.11±3.23)ng/mL,均低于常规组[(11.90±2.14)μmol/L、(37.25±6.58)mg/L、(29.23±3.74)μg/mL、(22.03±4.01)ng/mL],差异均有统计学意义(P<0.05)。治疗后,骨化三醇组25(OH)D、BAP、OPG水平均较治疗前升高,P1NP、β-CTX、ALP水平均较治疗前降低,差异均有统计学意义(P<0.05),常规组骨代谢指标治疗前后比较,差异均无统计学意义(P>0.05);骨化三醇组25(OH)D、BAP、OPG水平分别为(21.89±2.23)ng/mL、(38.98±4.74)μg/L、(312.52±34.41)ng/L,均高于常规组[(18.96±2.41)ng/mL、(31.52±4.06)μg/L、(279.96±31.04)ng/L],骨化三醇组P1NP、β-CTX、ALP水平分别为(41.66±4.26)ng/mL、(0.38±0.11)ng/mL、(5.08±0.89)U/L,均低于常规�Objective To observe the effects of calcitriol capsules combined with pancreatic kininogenase on the levels of homocysteine(Hcy),retinol-binding protein 4(RBP4)and amyloid A(SAA)in peripheral blood of patients with microvascular complications of type 2 diabetes mellitus.Methods A total of 104 patients with type 2 diabetes microvascular complications admitted to the Second Hospital of Qinhuangdao from January 2020 to December 2022 were prospectively selected and divided into conventional group(n=52)and calcitriol group(n=52)according to the random number table method.Both groups were treated with liraglutide,the conventional group plus pancreatic kininogenase,and the calcitriol group plus calcitriol capsules on the basis of the conventional group.The levels of glucose metabolism(fasting blood glucose,2 h postpranpranal blood glucose),Hcy,RBP4,SAA,pentamerin 3(PTX3)and bone metabolism indexes[25-hydroxyvitamin D(25(OH)D),bone alkaline phosphatase(BAP),osteopultin(OPG),type I procollagen amino terminal propeptide(P1NP),c-terminal telopeptide of type I collagen(β-CTX)and alkaline phosphatase(ALP)were compared between the two groups,and the adverse reactions between the two groups were analyzed].Results After treatment,the fasting blood glucose and 2-hour postprandial blood glucose of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05);however,there was no statistically significant difference between the calcitriol group and the conventional group(P>0.05).After treatment,the levels of Hcy,RBP4,SAA,and PTX3 in the calcitriol group and the conventional group were lower than those before treatment,and the differences were statistically significant(P<0.05),and the levels of Hcy,RBP4,SAA,and PTX3 in the calcitriol group were(10.23±2.06)μmol/L,(32.85±5.15)mg/L,(23.01±3.86)μg/mL,and(18.11±3.23)ng/mL,respectively,which were lower than those in the conventional group[(11.90±2.14)μmol/L,(37.25±6.58)mg/L,(29.23±3.74)μg/mL,(22.03±4.01)ng/mL],and the differe

关 键 词：2型糖尿病 骨化三醇胶丸 胰激肽原酶 微血管并发症 骨代谢 

分 类 号：R587.2[医药卫生—内分泌]