叶酸受体介导的宫颈特殊染色联合人乳头瘤病毒快速检测筛查宫颈病变的临床效果分析  

Clinical analysis of folic acid receptor-mediated cervical special staining combined with human papillomavirus rapid detection for screening cervical lesions

作　　者：郭萌 薛文彦 GUO Meng;XUE Wen-yan(Department of Obstetrics and Gynecology,Shaw Hospital Affiliated to Nanjing Medical University,Nanjing Jiangsu 210000,China)

机构地区：[1]南京医科大学附属逸夫医院妇产科,江苏南京210000

出　　处：《临床和实验医学杂志》2024年第1期73-77,共5页Journal of Clinical and Experimental Medicine

基　　金：国家自然科学基金(编号:81873820)。

摘　　要：目的研究叶酸受体介导的宫颈特殊染色(FRD)联合人乳头瘤病毒快速检测(Care HPV)筛查宫颈病变的临床效果。方法本研究方法为回顾性分析,观察对象为2018年1月至2022年12月南京医科大学附属逸夫医院收治入院的90例宫颈病变患者,参考筛查方式分为研究组(n=45)与对照组(n=45)。研究组行FRD联合Care HPV筛查,对照组行薄层液基细胞学检查(TCT)联合Aptima HPV筛查。比较两组患者的检测效果、症状自评效果[焦虑自评量表(SAS)、抑郁自评量表(SDS)、症状自评量表(SCL-90)、生活质量量表(SF-36)]、社会经济效果及并发症(人工流产综合征、感染、出血)发生情况。结果两组患者的宫颈病变阳性检出率、阴性预测值、阳性预测值、特异度、敏感度、漏诊率比较,差异均无统计学意义(P>0.05)。两组患者的SCL-90、SF-36评分比较,差异均无统计学意义(P>0.05);研究组患者的SAS、SDS评分分别为(53.16±6.92)、(52.26±6.74)分,均明显低于对照组[(56.19±6.75)、(55.18±6.63)分],差异均有统计学意义(P<0.05)。研究组患者的检测时间为(6.19±1.32)min,明显长于对照组[(2.52±0.89)min],报告时间为(25.00±3.00)h,明显短于对照组[(71.00±11.00)h],检测费用为(59.00±20.00)元,明显低于对照组[(561.00±98.00)元],差异均有统计学意义(P<0.05)。两组患者人工流产综合征发生率比较,差异无统计学意义(P>0.05);研究组患者的感染、出血发生率分别为0、8.89%,均明显低于对照组(8.89%、28.89%),差异均有统计学意义(P<0.05)。结论FRD联合Care HPV筛查与TCT联合Aptima HPV筛查宫颈病变均具有显著效果,但FRD联合Care HPV筛查方案相较于TCT联合Aptima HPV筛查方案的报告时间更短,检测费用更少,患者症状自评效果更佳,并发症更少。Objective To study the clinical effect of folate receptor-mediated special cervical staining(FRD)combined with human papillomavirus rapid test(Care HPV)in screening cervical lesions.Methods The study method was retrospective analysis.Ninety patients with cervical lesions admitted to Shaw Hospital Affiliated to Nanjing Medical University from January 2018 to December 2022 were divided into the study group(n=45)and the control group(n=45)according to screening methods.The study group underwent FRD combined Care HPV screening.The control group underwent thin-layer liquid-based cytology(TCT)combined with Aptima HPV screening.The detection effect,symptom self-assessment effect[self-rating anxiety scale(SAS),self-rating depression scale(SDS),symptom check list 90(SCL-90),the 36-item short form health survey(SF-36)],social and economic effect and complications(abortion syndrome,infection,bleeding)were compared between the two groups.Results There were no statistically significant differences in the detection rate,negative predictive value,positive predictive value,specificity,sensitivity and missed diagnosis rate between the two groups(P>0.05).There were no statistically significant differences in the scores of SCL-90 and SF-36 between the two groups(P>0.05).The scores of SAS and SDS in the study group were(53.16±6.92),(52.26±6.74)points,respectively,which were significantly lower than those in the control group[(56.19±6.75),(55.18±6.63)points],and the differences were statistically significant(P<0.05).The detection time of the study group was(6.19±1.32)min,which was significantly longer than that of the control group[(2.52±0.89)min],the reporting time was(25.00±3.00)h,which was significantly shorter than that of the control group[(71.00±11.00)h],and the detection cost was(59.00±20.00)yuan,which was significantly lower than that of the control group[(561.00±98.00)yuan],the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of abortion syndrome

关 键 词：宫颈病变 叶酸受体介导的宫颈特殊染色 人乳头瘤病毒快速检测 薄层液基细胞学检查 宫颈癌 

分 类 号：R711.3[医药卫生—妇产科学]