低强度脉冲超声对骨陷窝-骨小管系统的微观影响研究  

Study of microscopic effects of low-intensity pulsed ultrasound on bone lacunar-canalicular system

作　　者：王佳明 张晓光 李烜 吕林蔚 张春秋 WANG Jia-ming;ZHANG Xiao-guang;LI Xuan;LYU Lin-wei;ZHANG Chun-qiu(Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control,National Demonstration Center for Experimental Mechanical and Electrical Engineering Education,Tianjin University of Technology,Tianjin 300384,China;Tianjin Medical Device Evaluation and Inspection Center,Tianjin 300191,China)

机构地区：[1]天津理工大学机械工程学院天津市先进机电系统设计与智能控制重点实验室,机电工程国家级实验教学示范中心,天津300384 [2]天津市医疗器械审评查验中心,天津300191

出　　处：《医疗卫生装备》2023年第11期27-33,共7页Chinese Medical Equipment Journal

基　　金：国家自然科学基金项目(12072235);天津市自然科学基金项目(21JCYBJC00910)。

摘　　要：目的:研究低强度脉冲超声(low-intensity pulsed ultrasound,LIPUS)对骨陷窝-骨小管系统(lacunar-canalicular system,LCS)的微观影响。方法:选取骨组织中的3个连续的骨细胞,采用SolidWorks软件建立LCS模型,再将LCS模型导入有限元分析软件COMSOL中。在LCS模型顶部进行LIPUS照射,分析不同条件下LCS模型的声场和热场分布。结果:超声照射LCS模型后,距离超声入射面越远,声场声压越小,且模型内部的声压分布具有左右对称性;LCS模型内部的声场声压会随着激励声压的增强而增大;越接近超声聚焦区域,温度等值线越密集。结论:该研究揭示了微观角度下LCS内声场和热场的分布规律,为LIPUS实验和治疗提供了理论参考。Objective To explore the microscopic effects of low-intensity pulsed ultrasound(LIPUS)on bone lacunar-canalicular system(LCS).Methods Three consecutive bone cells from the real bone tissue were selected and used to build a LCS model with SolidWorks software,then the LCS model was imported into finite element analysis software COMSOL.LIPUS irradiation was performed on the top of the LCS model to analyze the distribution of the acoustic and thermal fields of the model under different conditions.Results After ultrasonic irradiation of the LCS model,the farther away from the ultrasonic incidence surface,the lower the acoustic field sound pressure was,and the distribution of the sound pressure inside the model had left-right symmetry;the acoustic field sound pressure inside the LCS model increased with the enhancement of the excitation sound pressure;the closer to the ultrasound focusing region,the denser the temperature contours.Conclusion The distribution laws of acoustic and thermal fields within the LCS are revealed from a microscopic point of view,and theoretical references are provided for LIPUS experiments and treatment.

关 键 词：低强度脉冲超声 骨陷窝-骨小管系统 声场分布 热场分布 骨质疏松 

分 类 号：R318[医药卫生—生物医学工程]