乙型肝炎核心抗体定量测定的临床意义及研究进展  

Clinical significance and research progress of quantitative hepatitis B virus core antibody measurement

作　　者：刘艺琪 张驰 赵鸿[1,2] 王贵强 Liu Yiqi;Zhang Chi;Zhao Hong;Wang Guiqiang(Department of Infectious Disease and the Center for Liver Diseases,Peking University First Hospital,Beijing 100034,China;Department of Infectious Disease,Peking University International Hospital,Beijing 102206,China;Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases,Beijing 100044,China)

机构地区：[1]北京大学第一医院感染疾病科暨肝病中心,北京100034 [2]北京大学国际医院感染疾病科,北京102206 [3]丙型肝炎和肝病免疫治疗北京市重点实验室,北京100044

出　　处：《中华肝脏病杂志》2024年第1期83-86,共4页Chinese Journal of Hepatology

基　　金：国家自然科学基金项目 (82270626)。

摘　　要：乙型肝炎核心抗体是病毒感染后产生的特异性抗体,出现早,持续时间长,利用双抗原夹心化学发光微粒子免疫检测法测量其在血清中的水平,具有更高的灵敏度和特异性,为乙肝患者的诊断、治疗及停药管理提供新的临床指标。本文就乙肝核心抗体定量检测的临床意义及研究进展作综述,阐述其在临床实践中的研究应用及前景。Hepatitis B virus core antibodies are specific antibodies produced after viral infection that appear early and last for a long time,and its levels in serum are measured by the double-antigen sandwich chemiluminescent microparticle immunoassay method,which has higher sensitivity and specificity,providing new clinical indicators for hepatitis B patients diagnosis,treatment,and drug withdrawal management.This article reviews the clinical significance and research progress of quantitative hepatitis B core antibody measurement and expounds on its research applications and prospects in clinical practice.

关 键 词：肝纤维化 乙型肝炎核心抗体定量 肝脏炎症 复发 再激活 

分 类 号：R512.62[医药卫生—内科学]