全身PET/CT 1 min采集图像与常规PET/CT图像质量比较:自身对照研究  

Comparison of the image quality between total-body PET/CT with 1 min acquisition and conventional PET/CT: a self-control study

作　　者：杨润君 陈雪琪 余浩军 胡鹏程 石洪成 Yang Runjun;Chen Xueqi;Yu Haojun;Hu Pengcheng;Shi Hongcheng(Department of Nuclear Medicine,Zhongshan Hospital,Fudan University Nuclear Medicine Institute of Fudan University Shanghai Institution of Medical imaging,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院核医学科、复旦大学核医学研究所、上海市影像医学研究所,上海200032

出　　处：《中华核医学与分子影像杂志》2024年第1期12-15,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：上海市临床重点专科项目(shslczdzk03401);促进市级医院临床技能与临床创新能力三年行动计划项目(SHDC2020CR3079B)。

摘　　要：目的探讨全身PET/CT(TB PET/CT)1 min采集图像质量能否满足临床诊断需求。方法回顾性分析2019年5月至2021年9月间复旦大学附属中山医院病理证实的90例肿瘤患者(男60例、女30例, 年龄31~86岁)PET/CT影像资料。注射18F-FDG后, 患者按照顺序随机原则先后完成TB PET/CT 1 min采集及常规PET/CT(C PET/CT)常规图像采集, 采用配对样本t检验或Wilcoxon符号秩检验比较不同PET/CT采集所获得的图像质量。结果 C PET/CT 1 min采集与TB PET/CT 1 min采集的病灶SUVmax分别为12.5(5.8, 16.6)和15.9(7.9, 24.6)(z=8.14, P<0.001), 纵隔血池、肝脏、肌肉的信噪比(SNR)分别为6.2±1.7、9.4(7.7, 11.8)、6.0(4.9, 7.1)与9.3±3.0、11.4(9.5, 14.2)、8.3(7.3, 10.1), 肿瘤-血池比(TBR)、肿瘤-肝脏比(TLR)、肿瘤-肌肉比(TMR)分别为8.5(4.3, 11.1)、6.1(2.9, 7.7)、18.3(9.6, 26.6)和9.3(4.3, 14.8)、6.7(3.0, 10.4)、23.2(11.5, 38.0), 差异均有统计学意义(t=9.36, z值:4.44~7.40, 均P<0.001)。结论 TB PET/CT 1 min采集的图像质量能够满足诊断需求, 且优于C PET/CT常规采集的图像。Objective To investigate whether the image quality of total-body PET/CT(TB PET/CT)with 1 min acquisition can meet the clinical diagnostic requirements.Methods From May 2019 to September 2021,a total of 90 malignant tumor patients(60 males,30 females,age 31-86 years)with primary lesions confirmed by pathological diagnosis in Zhongshan Hospital,Fudan University were respectively analyzed.All patients underwent conventional PET/CT(C PET/CT)scan with conventional clinical acquisition and TB PET/CT scan with 1 min acquisition after injecting 18F-FDG in random order.Paired t test or Wilcoxon signed rank test was used to analyze the image quality of these two scans.Results SUVmax of primary lesions in TB PET/CT group was significantly higher than that in C PET/CT group(15.9(7.9,24.6)vs 12.5(5.8,16.6);z=8.14,P<0.001),so were signal-to-noise ratio(SNR)of the blood pool,liver,muscles(9.3±3.0,11.4(9.5,14.2),8.3(7.3,10.1)vs 6.2±1.7,9.4(7.7,11.8),6.0(4.9,7.1)),tumor-to-blood pool ratio(TBR)(9.3(4.3,14.8)vs 8.5(4.3,11.1)),tumor-to-liver ratio(TLR)(6.7(3.0,10.4)vs 6.1(2.9,7.7)),tumor-to-muscle ratio(TMR)(23.2(11.5,38.0)vs 18.3(9.6,26.6);t=9.36,z values:4.44-7.40,all P<0.001).Conclusion The image quality of TB PET/CT scan with 1 min acquisition can meet the diagnostic requirements,and is better than the C PET/CT image quality with conventional clinical acquisition.

关 键 词：图像处理 计算机辅助 时间因素 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 

分 类 号：R817.4[医药卫生—影像医学与核医学] R730.44[医药卫生—放射医学]