离子通道与玫瑰痤疮发病机制的研究进展  

Role of ion channels in the pathogenesis of rosacea

作　　者：魏子妤 杨勇 Wei Ziyu;Yang Yong(Genetic Skin Disease Center,Hospital for Skin Diseases,Institute of Dermatology,Chinese Academy of Medical Sciences&Peking Union Medical College,Nanjing 210042,China)

机构地区：[1]中国医学科学院、北京协和医学院皮肤病医院遗传病中心,南京210042

出　　处：《中华皮肤科杂志》2024年第2期174-177,共4页Chinese Journal of Dermatology

基　　金：国家自然科学基金(82130091)。

摘　　要：外界理化因素和情绪改变等会诱发玫瑰痤疮患者出现面部阵发性潮红,并伴有灼热、刺痛和瘙痒感。大量研究提示,离子通道激活后释放神经肽诱导的神经血管失调和神经源性炎症与玫瑰痤疮发病相关。本文综述近年来离子通道与玫瑰痤疮发病机制的研究进展,为以离子通道作为玫瑰痤疮的治疗靶点提供依据。External physicochemical factors and emotional changes often lead to intermittent facial flushing in patients with rosacea,accompanied by burning,stinging,and itching sensations.Many studies have demonstrated that neurovascular dysfunction and neurogenic inflammation induced by neuropeptides released following the activation of ion channels were associated with the occurrence of rosacea.This review summarizes research progress on the role of ion channels in the pathogenesis of rosacea and provides evidence for further research on ion channels as potential therapeutic targets for rosacea.

关 键 词：红斑痤疮 瞬时受体电位离子通道 电压门控钠离子通道 神经肽类 神经血管 神经源性炎症 紧密连接蛋白 

分 类 号：R758.734[医药卫生—皮肤病学与性病学]