Construction of meloxicam and bupivacaine co-delivery nanosystem based on the pathophysiological environment of surgical injuries for enhanced postoperative analgesia  

作　　者：Mohan Li Yumiao He Zongran Liu Xu Ma Fengrun Sun Lijian Pei Chao Ma Hongju Liu Tianjiao Ji Yuguang Huang 

机构地区：[1]Department of Anesthesiology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China [2]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center of Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing 100190,China [3]Department of Human Anatomy,Histology and Embryology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005,China [4]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Nano Research》2023年第12期13301-13308,共8页纳米研究（英文版）

基　　金：supported by the National High Level Hospital Clinical Research Funding(Nos.2022-PUMCH-B-006 and 2022-PUMCH-C-067);the National Natural Science Foundation of China(No.32271391);Beijing Natural Science Foundation(No.Z220022).

摘　　要：Besides peripheral nerve injury,the acute inflammation is one of the pathological features of tissues after surgery,which exacerbates the postoperative pain,especially in the first 48 h after the surgery.Multimodal analgesia(MMA),such as the combination of non-steroidal anti-inflammatory drugs(NSAIDs)with local anesthetics,has shown enhanced potency compared with the usage of local anesthetics alone.However,rare formulations can provide long-term analgesia at a single dose.Herein,bupivacaine(BUP,a local anesthetic)loading poly(lactic-co-glycolic acid)(PLGA)nanoparticles(NPB)were coated with meloxicam(MLX,an NSAID)loading lipid bilayer(LPM),forming a core–shell nanosystem(NPB@LPM)to provide enhanced and long-term analgesia to treat postoperative pain.MLX was encapsulated in the lipid shell,which enabled high dose MLX to be released in the first 48 h after surgery to reduce the acute inflammation induced pain.BUP was encapsulated in the PLGA core to provide a long-term release for the nerve block.This nanosystem provided a 7-day(whole recovery cycle)effective analgesia in the Brennan’s plantar incision rat model.The tissue reactions of NPB@LPM are benign.This work will provide feasible strategies on designing drug delivery systems for postoperative pain management.

关 键 词：core–shell nanostructure multimodal analgesia co-delivery system postoperative pain management 

分 类 号：R318[医药卫生—生物医学工程]