Intravascular photoacoustic and optical coherence tomography imaging dual-mode system for detecting spontaneous coronary artery dissection: A feasibility study  

作　　者：Yongwei Wang Yuyang Wan Zhongjiang Chen 

机构地区：[1]MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science,South China Normal University Guangzhou 510631,P.R.China [2]College of Biophotonics South China Normal University Guangzhou 510631,P.R.China [3]School of Medical Technology and Engineering Fujian Medical University Fuzhou 350004,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》2024年第1期77-86,共10页创新光学健康科学杂志（英文）

基　　金：funding from the National Natural Science Foundation of China(NSFC)under grants 61627827,61705068;the Natural Science Foundation of Fujian Province 2021J01813;the Fujian Medical University Research Foundation of Talented Scholars XRCZX2021004.

摘　　要：In this work,we present an intravascular dual-mode endoscopic system capable of both intravascular photoacoustic imaging(IVPAI)and intravascular optical coherence tomography(IVOCT)for recognizing spontaneous coronary artery dissection(SCAD)phantoms.IVPAI provides high-resolution and high-penetration images of intramural hematoma(IMH)at different depths,so it is especially useful for imaging deep blood clots associated with imaging phantoms.IVOCT can readily visualize the double-lumen morphology of blood vessel walls to identify intimal tears.We also demonstrate the capability of this dual-mode endoscopic system using mimicking phantoms and biological samples of blood clots in ex vivo porcine arteries.The results of the experiments indicate that the combined IVPAI and IVOCT technique has the potential to provide a more accurate SCAD assessment method for clinical applications.

关 键 词：Spontaneous coronary artery dissection(SCAD) intravascular optical coherence tomography(IVOCT) intravascular photoacoustic imaging(IVPAI) 

分 类 号：R543.3[医药卫生—心血管疾病]