Adenylate cyclase activates the cAMP signalling pathway to enhance platelet-rich plasma-treated Achilles tendon disease,a theoretical bioinformatics-based study  

作　　者：Jing-Yi Sun Cai Li Feng-Ying Du 

机构地区：[1]College of Basic Medical Science,Qilu Medical University,Zibo 255300,Shandong Province,China [2]Department of Gastroenterological Surgery,Shandong Provincial Hospital of Shandong First Medical University,Jinan 250021,Shandong Province,China

出　　处：《World Journal of Orthopedics》2024年第2期192-200,共9页世界骨科杂志（英文版）

摘　　要：The effectiveness of platelet-rich plasma(PRP)for the treatment of Achilles tendon disorders still needs to be evaluated through a series of prospective studies,but genomic analysis can reveal the existence of complementary PRP treatment options.Based on the 96 platelet activation-related genes in the Kyoto Encyclopedia of Genes and Genomes(KEGG)database,we performed Gene Ontology functional enrichment analysis and KEGG enrichment analysis,pathway correlation analysis,and enrichment mapping to determine the enrichment results of the gene set enrichment analysis and found that the cAMP signalling pathway may be the key to enhancing the effectiveness of PRP treatment.The cAMP signalling pathway interacts with the Rap1 signalling pathway and cGMPPKG signalling pathway to mediate the entire pathophy-siological process of Achilles tendon disease.Moreover,ADCY1-9 may be the key to the activation of the cAMP signalling network.Further based on the data in the Gene Expression Omnibus database,it was found that ADCY4 and ADCY7 may be the players that play a major role,associated with the STAT4-ADCY4-LAMA5 axis and the GRbeta-ADCY7-SEMA3C axis,which is expected to be a complementary target for enhancing the efficacy of PRP in the treatment of Achilles tendon disease.

关 键 词：Platelet-rich plasma Achilles tendon disease CAMP Adenylate cyclase Complementary target 

分 类 号：R686[医药卫生—骨科学]