Pathological diagnosis and immunohistochemical analysis of giant retrosternal goiter in the elderly: A case report  

作　　者：Yong-Chang Meng Liu-Sheng Wu Ning Li Hong-Wei Li Jing Zhao Jun Yan Xiao-Qiang Li Peng Li Jiang-Qi Wei 

机构地区：[1]Department of Cardiothoracic Surgery,Xinxiang First People's Hospital,Xinxiang 453000,Henan Province,China [2]School of Clinical Medicine,Tsinghua University,Beijing 100084,China [3]Graduate School,Qinghai University,Xining 810016,Qinghai Province,China [4]Department of Pathology,Xinxiang First People's Hospital,Xinxiang 453000,Henan Province,China [5]Department of Thoracic Surgery,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2024年第3期643-649,共7页世界临床病例杂志

基　　金：Supported by the Scientific Research Foundation of Peking University Shenzhen Hospital,No.KYQD202100X;the National Natural Science Foundation of China,No.81972829;and Precision Medicine Research Program of Tsinghua University,No.2022ZLA006。

摘　　要：BACKGROUND Elderly giant retrosternal thyroid goiter is a rare yet significant medical condition,often presenting clinical symptoms that can be confused with other diseases,posing diagnostic and therapeutic challenges.This study aims to delve into the characteristics and potential mechanisms of this ailment through pathological diagnosis and immunohistochemical analysis,providing clinicians with more precise diagnostic and treatment strategies.A 77-year-old male,was admitted to hospital with the chief complaint of finding a goiter in the semilunar month during physical examination,accompanied by dyspnea.Locally protruding into the superior mediastinum,the adjacent structure was compressed,the trachea was compressed to the right,and the local lumen was slightly narrowed.The patient was diagnosed with giant retrosternal goiter.Considering dyspnea caused by trachea compression,our department planned to perform giant retrosternal thyroidectomy.Immunohistochemical results:Tg(+),TTF-1(+),Calcitonin(CT)(I),Ki-67(+,about 20%),CD34(-).Retrosternal goiter means that more than 50%of the volume of the thyroid gland is below the upper margin of the sternum.As retrosternal goiter disease is a relatively rare disease,once the disease is diagnosed,it should be timely surgical treatment,and the treatment is more difficult,the need for professional medical team for comprehensive treatment.CONCLUSION The imaging manifestations of giant retrosternal goiter are atypical,histomorphology and immunohistochemistry can assist in its diagnosis.This article reviews the relevant literature of giant retrosternal goiter immunohisto-chemistry and shows that giant retrosternal goiter is positive for Tg,TTF-1,and Ki-67.

关 键 词：Giant retrosternal goiter Pathology IMMUNOHISTOCHEMISTRY Case report 

分 类 号：R581[医药卫生—内分泌]