Unraveling the efficacy network: A network meta-analysis of adjuvant external beam radiation therapy methods after hepatectomy  

作　　者：Gao-Yuan Yang Zhi-Wei He Yong-Chang Tang Feng Yuan Ming-Bo Cao Yu-Peng Ren Yu-Xuan Li Xiao-Rui Su Zhi-Cheng Yao Mei-Hai Deng 

机构地区：[1]Department of Hepatobiliary Surgery,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,Guangdong Province,China [2]Department of General Surgery,Qilu Hospital,Shandong University,Jinan 250012,Shandong Province,China [3]Department of General Surgery,The First Affiliated Hospital,Guangzhou Medical University,Guangzhou 511436,Guangdong Province,China [4]Department of Hepatobiliary and Pancreatic Surgery,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,Guangdong Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第1期205-214,共10页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by The Science and Technology Plan Project of Guangzhou,No.202102010171;National Natural Science Foundation。

摘　　要：BACKGROUND Primary liver cancer is a malignant tumor with a high recurrence rate that significantly affects patient prognosis.Postoperative adjuvant external radiation therapy(RT)has been shown to effectively prevent recurrence after liver cancer resection.However,there are multiple RT techniques available,and the differ-ential effects of these techniques in preventing postoperative liver cancer re-currence require further investigation.AIM To assess the advantages and disadvantages of various adjuvant external RT methods after liver resection based on overall survival(OS)and disease-free survival(DFS)and to determine the optimal strategy.METHODS This study involved network meta-analyses and followed the PRISMA guidelines.The data of qualified studies published before July 10,2023,were collected from PubMed,Embase,the Web of Science,and the Cochrane Library.We included relevant studies on postoperative external beam RT after liver resection that had OS and DFS as the primary endpoints.The magnitudes of the effects were determined using risk ratios with 95%confidential intervals.The results were analyzed using R software and STATA software.RESULTS A total of 12 studies,including 1265 patients with hepatocellular carcinoma(HCC)after liver resection,were included in this study.There was no significant heterogeneity in the direct paired comparisons,and there were no significant differences in the inclusion or exclusion criteria,intervention measures,or outcome indicators,meeting the assumptions of heterogeneity and transitivity.OS analysis revealed that patients who underwent stereotactic body radiotherapy(SBRT)after resection had longer OS than those who underwent intensity modulated radiotherapy(IMRT)or 3-dimensional conformal RT(3D-CRT).DFS analysis revealed that patients who underwent 3D-CRT after resection had the longest DFS.Patients who underwent IMRT after resection had longer OS than those who underwent 3D-CRT and longer DFS than those who underwent SBRT.CONCLUSION HCC patients who undergo liver cancer resec

关 键 词：Primary liver cancer Hepatocellular carcinoma Network meta-analysis External beam radiation therapy Stereotactic body radiotherapy Intensity modulated radiotherapy 

分 类 号：R657.3[医药卫生—外科学]