吲哚羧酸类Dy(Ⅲ)配合物与DNA作用机制研究  

The DNA interaction mechanism with a Dy(Ⅲ)complex based on indolecarboxylic acid

作　　者：罗思雨 朱小双 何秋蓉 王思茗 李冰[1] LUO Siyu;ZHU Xiaoshuang;HE Qiurong;WANG Siming;LI Bing(College of Chemistry and Chemical Engineering of Ningxia University,Yinchuan Ningxia 750021,China)

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021

出　　处：《石油化工应用》2024年第1期105-107,121,共4页Petrochemical Industry Application

基　　金：宁夏大学大学生创新创业训练计划自治区级项目(S202310749141)。

摘　　要：以7-氮杂吲哚-3-羧酸(7AI_(3)CAH_(2))为配体构筑了一例新型稀土Dy(Ⅲ)配合物[Dy(7AI_(3)CAH)_(2)(NO_(3))(H_(2)O)_(2)],利用元素分析、红外光谱、热重分析等对其进行结构表征。黏度法和荧光光谱表明该配合物与小牛胸腺DNA(CT-DNA)间结合模式为嵌插结合,配合物与CT-DNA表现出良好结合作用。A new Dy(Ⅲ)-based complex[Dy(7AI_(3)CAH)_(2)(NO_(3))(H_(2)O)_(2)]was constructed using 7-azindole-3-carboxylic acid(7AI_(3)CAH_(2))as the ligand.Elemental analysis,infrared spectroscopy,thermogravimetric analysis were used to determine the structure of the complex.Fluorescence spectroscopy and viscometry showed that the binding mode between the complex and calf thymus DNA(CT-DNA)was intercalation binding,and the complex showed good binding to CT-DNA.

关 键 词：配合物 7-氮杂吲哚-3-羧酸 小牛胸腺DNA 

分 类 号：O622.5[理学—有机化学]