微针技术用于非经皮途径的药物递送研究进展  

Applications of microneedles in non-transdermal drug delivery:a review

作　　者：王开楠 职康康 WANG Kainan;ZHI Kangkang(School of Health Science and Engineering,Shanghai University for Science and Technology,Shanghai 200093,China;Department of Vascular Surgery,Changzheng Hospital,Naval Military Medical University,Shanghai 200003,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]海军军医大学附属长征医院血管外科,上海200003

出　　处：《生物工程学报》2024年第2期446-457,共12页Chinese Journal of Biotechnology

基　　金：上海市科委“科技创新行动计划”生物医药科技支撑专项项目(20S31902000)。

摘　　要：近年来,微针作为一种新兴的经皮给药技术,具有微创、无痛、使用方便和高效的特点,逐渐成为一种极具研究价值和应用潜力的给药策略。微针技术在过去20年中得到迅速发展并呈现出多样化的趋势,已可根据不同需求来定制微针的形状、组成、机械性能和其他特殊功能等。由于微针能以微创方式穿越各种生物屏障,因此许多研究人员探索了微针在除皮肤外各类组织和器官中的药物递送应用。本文综述了微针技术及其近年来在眼睛、血管、心脏等组织和器官的药物递送中的应用研究,以期推动微针技术的应用发展。In recent years,microneedles have emerged as a drug delivery technology that holds great research value and application potential due to their minimally invasive,painless,user-friendly,and efficient characteristics.The technology of microneedles has rapidly evolved over the past 20 years,allowing customization of shape,composition,mechanical properties,and unique functions to meet diverse needs.With the ability to minimally invasively traverse various biological barriers,researchers have explored the applications of microneedles in various tissues and organs beyond the skin.This article summarizes the research progress on the use of microneedles for drug delivery in tissues such as eyes,blood vessel,and heart.By presenting these cutting-edge research to readers,we hope to promote the development and application of microneedle technology.

关 键 词：微针 生物屏障 药物递送 

分 类 号：R943[医药卫生—药剂学]