黏蛋白1与呼吸系统疾病关系的研究进展  

Research Progress of Correlation between Mucin 1 and Respiratory Diseases

作　　者：吴静[1] 程梓荷 王蒙蒙[1] 孙亚楠 王巧云 李田田 姚杨[1] 王胜昱[1] WU Jing;CHENG Zihe;WANG Mengmeng;SUN Yanan;WANG Qiaoyun;LI Tiantian;YAO Yang;WANG Shengyu(Department of Pulmonary and Critical Medicine,the First Affiliated Hospital of Xi′an Medical University,Xi′an 710077,China)

机构地区：[1]西安医学院第一附属医院呼吸与危重症医学科,西安710077

出　　处：《医学综述》2024年第3期279-283,共5页Medical Recapitulate

基　　金：西安市第七批科技计划项目(20YXYJ0001)。

摘　　要：慢性黏液高分泌导致的气道炎症可能会逐渐进展并影响患者的肺功能。黏液蛋白是黏液层的关键成分,其中黏蛋白1是一种重要的膜结合型黏蛋白,目前的研究聚焦于评估黏蛋白1在肺纤维化、肺癌和间质性肺疾病等肺部疾病中的临床应用,尤其是作为诊断、预测进展和评估治疗效果的生物标志物。因此,深入了解黏蛋白1在肺部疾病中的生物学机制和作用方式,特别是与疾病发展和进展的关联,探索黏蛋白1在肺部疾病早期诊断和预后评估中的预测价值,将为肺部疾病的诊断和治疗提供新的理论依据。Chronic mucus hypersecretion can lead to progressive airway inflammation and impair lung function.Mucins are key components of the mucus layer,with mucin 1 being an important membrane-bound mucin.Current research focuses on evaluating the clinical applications of mucin 1 in pulmonary diseases such as pulmonary fibrosis,lung cancer,and interstitial lung diseases,particularly as a biomarker for the diagnosis,predicting disease progression,and assessing treatment efficacy.Therefore,gaining a deeper understanding of the biological mechanisms and role of mucin 1 in pulmonary diseases,especially its association with the disease development and progression,and exploring its predictive value in the early diagnosis and prognosis assessment,will provide new theoretical basis for the diagnosis and treatment of pulmonary diseases.

关 键 词：急性呼吸窘迫综合征 间质性肺疾病 慢性阻塞性肺疾病 肺癌 黏蛋白1 

分 类 号：R563[医药卫生—呼吸系统]