基于中医传承辅助平台健脾祛痰法治疗高血压用药规律分析  

Analysis of medication rules in the treatment of hypertension using strengthening spleen and dispelling phlegm methods based on traditional Chinese medicine inheritance support system

作　　者：付天骄 李思琦[2] 李晓莹 王惠莹 梁太守 FU Tianjiao;LI Siqi;LI Xiaoying;WANG Huiying;LIANG Taishou(School of Graduate,Liaoning University of Traditional Chinese Medicine,Liaoning,Shenyang 110847,China;Department of Cardiology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学研究生学院,辽宁沈阳110847 [2]辽宁中医药大学附属医院心内科,辽宁沈阳110032

出　　处：《中国医药科学》2024年第2期12-14,19,共4页China Medicine And Pharmacy

基　　金：辽宁省沈阳市科技计划项目(21-174-9-04)。

摘　　要：目的利用数据挖掘技术分析中医药应用健脾祛痰法治疗高血压的组方用药规律。方法收集中国知网、维普、万方数据库2003年1月至2023年1月应用健脾祛痰法治疗高血压的临床方剂,借助中医传承辅助平台的统计挖掘功能,分析常用中药的性味归经、功效、频次等,以及基于关联规则的药对配伍和基于聚类分析的核心组合等用药规律。结果共纳入方剂116首,涉及中药205味,以温、平性,甘、苦、辛味药物为主;主归脾、肝、肺经,使用频次≥15次的茯苓、半夏等20味中药,主要为补虚药、平肝息风药和利水渗湿类;挖掘出7条关联规则,茯苓-白术-天麻-陈皮→半夏等,得到6个核心组方,为二陈汤的类方。结论应用健脾祛痰法治疗高血压用药符合健脾祛湿、化痰熄风的治法,兼以活血、清热、补肾,体现了“治病必求于本”,重视调补脾胃的中医思想。Objective To use data mining technology to analyze the prescription and medication rules of traditional Chinese medicine in the treatment of hypertension using the method of strengthening spleen and dispelling phlegm.Methods The clinical prescriptions for the treatment of hypertension using the method of strengthening the spleen and expelling phlegm from January 2003 to January 2023 in the databases of CNKI,VIP,and Wanfang were collected.With the statistical mining function of the traditional Chinese medicine inheritance support system,the characteristics,taste,meridian tropism,efficacy,frequency,etc.of commonly used traditional Chinese medicine,and the drug pair compatibility based on association rules and the core combination based on cluster analysis.Results A total of 116 prescriptions were included,involving 205 traditional Chinese medicines,with mild effects.Mainly using sweet,bitter,and spicy drugs.20 traditional Chinese medicines,such as poria cocos and pinellia ternata,were mainly used in the spleen,liver,and lung meridians,with a frequency of≥15 times.They were mainly tonifying herbs,liver calming medicine,and diffusing dampness medicine.Excavated 7 association rules,such as poria cocos,atractylodes macrocephala,gastrodia elata,dried tangerine peel,pinellia ternata,etc.,and obtained 6 core prescriptions,which were similar to Erchen decoction.Conclusion The application of the method of strengthening spleen and dispelling phlegm to treat hypertension is in line with the treatment methods of strengthening the spleen and dispelling dampness,resolving phlegm and claiming Qi.It also promotes blood circulation,clearing heat,and tonifying the kidney,reflecting the traditional Chinese medicine philosophy of"treating diseases must be based on the root cause"and emphasizing the regulation of the spleen and stomach.

关 键 词：高血压 健脾祛痰 聚类分析 用药规律 

分 类 号：R259[医药卫生—中西医结合]