CYP2C19基因型与药物代谢相关性研究进展  

Research progress on the correlation between CYP2C19 genotype and drug metabolism

作　　者：安向阳 王颖 刘贤[3] 崔超[4] 周波[4] AN Xiangyang;WANG Ying;LIU Xian;CUI Chao;ZHOU Bo(Maternal Fetal Medicine Ward,the Affiliated Taian City Central Hospital of Qingdao University,Shandong,Taian 271000,China;Department of Pharmacy,Xintai Hospital of Traditional Chinese Medicine,Shandong,Xintai 271200,China;Endoscopy Room,the Affiliated Hospital of Qingdao University,Shandong,Qingdao 266003,China;Postdoctoral Research Workstations,the Affiliated Taian City Central Hospital of Qingdao University,Shandong,Taian 271000,China)

机构地区：[1]青岛大学附属泰安市中心医院母胎医学病房,山东泰安271000 [2]山东省新泰市中医医院药学部,山东新泰271200 [3]青岛大学附属医院内镜室,山东青岛266003 [4]青岛大学附属泰安市中心医院博士后科研工作站,山东泰安271000

出　　处：《中国医药科学》2024年第2期36-39,共4页China Medicine And Pharmacy

基　　金：山东省泰安市科技创新发展项目(2020NS141,2021NS372)。

摘　　要：细胞色素P450(CYP450)家族是人体内最重要的药物氧化代谢酶之一,而细胞色素P4502C19(CYP2C19)是CYP450家族中重要一员,参与许多药物的氧化代谢。药物代谢酶的基因多态性被认为是个体间药物反应差异最主要的原因,CYP2C19基因多态性影响许多药物的代谢,并与几种常用处方药的临床疗效和安全性问题密切相关。根据CYP2C19基因多态性可将人群分为慢代谢型、中间代谢型、正常代谢型和超快代谢型四大类。本文主要介绍CYP2C19基因多态性与其代谢药物相关性的研究进展,以期为临床个体化合理用药提供参考依据。The cytochrome P450(CYP450)family is one of the most important drug oxidative metabolic enzymes in the human body,and cytochrome P4502C19(CYP2C19)is an important member of the CYP450 family,participating in the oxidative metabolism of many drugs.The gene polymorphism of drug metabolic enzymes is considered to be the main reason for differences in drug response among individuals.The CYP2C19 gene polymorphism affects the metabolism of many drugs and is closely related to the clinical efficacy and safety issues of several commonly used prescription drugs.According to the CYP2C19 gene polymorphism,the population can be divided into four categories:slow metabolism type,intermediate metabolism type,normal metabolism type,and ultrafast metabolism type.The article mainly introduces the research progress on the correlation between CYP2C19 gene polymorphism and metabolic drugs,to provide a reference basis for clinical indi vidualized and rational drug use.

关 键 词：细胞色素P450 CYP2C19 基因多态性 药物代谢 

分 类 号：R96[医药卫生—药理学]